ID A0A1G7FI31_9SPHN Unreviewed; 989 AA.
AC A0A1G7FI31;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Zinc protease {ECO:0000313|EMBL:SDE75606.1};
GN ORFNames=SAMN05216557_101418 {ECO:0000313|EMBL:SDE75606.1};
OS Sphingomonas carotinifaciens.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1166323 {ECO:0000313|EMBL:SDE75606.1, ECO:0000313|Proteomes:UP000323502};
RN [1] {ECO:0000313|EMBL:SDE75606.1, ECO:0000313|Proteomes:UP000323502}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S7-754 {ECO:0000313|EMBL:SDE75606.1,
RC ECO:0000313|Proteomes:UP000323502};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; FNBI01000001; SDE75606.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7FI31; -.
DR Proteomes; UP000323502; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 3.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SDE75606.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000323502};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 114..250
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 264..440
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 759..919
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 312..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 106012 MW; DB304B541D6EBFB1 CRC64;
MRRAWLAEGA ASGYRVVPMA FPSRAYRAPV LLFLGLGLAG LAPVSGQQAP APQAAPVAPV
QQPAPAAVPP IPGVDQTPWL YKGSDLPQDK AWAFGTLPNG LRYAVRKNGV PPGQVAVRVR
IDAGSLNERD SERGFAHFIE HLSFRGSEYV PDGEAKRIWQ RFGATFGSDS NASTTPTQTV
YKLDLPGATE AGLDESLKIL SGMMEKPALT DAALAAERPV VLAERREQPG PQVRWSDKLR
ETFFAGQPLS QRSPIGQVET LQAATAASVR AFHDRWYRPE RAVVIISGDM DPAVFARLIA
KNFADWKGVG EKPVDPDFGT PQADQPPSAS IAEPGLPPVV VMGVMRPWRY QDDTIIFNQK
RLVDMLATRL ISRRLETRAR AGGSFLQAGV SLDDVSRSAN LTAVNIVPVG DDWEAALKDV
RAVIADAMAT APGQAEVDRE LTDFDTIMRT QVETARVEAG ARQADDMVEA LDIRETVTGP
ETSYAILKDA IAKKMFTPET LLASTRKIFQ GDATRALVNT RSPDPGVATK LAAALKADVS
ALAGKRRQQA NVTFAQLPRL GTPGKVVSRQ AIPALDMEQV VFANGVRLLL FPNASETGRV
YLRARFGQGY NALPANRESP IWAADLALMA GGIGKLDQGD LDQLSAGRRL GLDFGIENDA
FALGAITSPS DYADNLQLMA AKLAAPAWDP APLTRAKAVV RAAYAGFSAS PDGVISRDLE
RLLHDGDPRW GTPTPEVVAG TTPAAFKALW APLLASGPIE VSVFGDVKAD EAIAAVGRTF
GALKPRPAAT GAAPAIRFPA HVAAPVVRTH DGAADQAAAV IAWPTGGGSA DWRDRTRLDV
LAQVFSDRLF DRLRSEAGAS YTPQVASQWP IGLSGGGRMI AIGQVAPDKV DFFFTLAREI
AADLVANPIG ADELQRIKRP MGQFILRASS GNQFWLQQLG GASFDPKRVE ATQQLAQDFV
SIDPAQLQAV AVKYLRPERD WTLKVVPKK
//
