ID A0A1G7GJD4_9BACL Unreviewed; 746 AA.
AC A0A1G7GJD4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=SAMN04488542_10379 {ECO:0000313|EMBL:SDE88173.1};
OS Fontibacillus panacisegetis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Fontibacillus.
OX NCBI_TaxID=670482 {ECO:0000313|EMBL:SDE88173.1, ECO:0000313|Proteomes:UP000198972};
RN [1] {ECO:0000313|EMBL:SDE88173.1, ECO:0000313|Proteomes:UP000198972}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28129 {ECO:0000313|EMBL:SDE88173.1,
RC ECO:0000313|Proteomes:UP000198972};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FNBG01000003; SDE88173.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7GJD4; -.
DR STRING; 670482.SAMN04488542_10379; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000198972; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SDE88173.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198972};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 2..134
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 434..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 83977 MW; A396EBF813148993 CRC64;
MKTLVIAEKP DMGRTIAAVI EPRAKNNRSY LEGEHYIITW AIGHLLGLAE PDAYDDKYKR
WNFGDLPILP QQFKIVPNPK TKDQLKTIGE LSKRCNAVVN ACDAGREGQY IFDLIQQHIK
LDQPVKRLWI SDLTAESIAK GFEGLHEGRE FHNLTLAARA RSEADWLVGM NASRAFTTKH
NTLLSVGRVQ TPVLALIYDR QKEIESFDSL TYYDIKAVFQ QLERSYTGTW QGDRLTDGEK
AASIAEKVRG KAGAITSYEV KETKEYPYKL YDLTLLQREA NAKYGYSAKK TLDLAQALYE
RHKVISYPRT SSNYVNEQNI DGMHKALHML KSTSYRDLAE GANQSIVNVN NKSVCNPSRV
EDHHAILPTL RRAGNLSKEE QDIYDLVIRR FLSHFYPPAE YKQHTVLTEV ESETFKTNVK
ELLFLGWKVC QPNEDNSKSS GKGRKKEEED EAEELVSEPF HINPEEKVHC SEVEVKEKAT
QPPKSYTEGT LLKAMESAGK QLENEELRDA MKEGGLGTPA TRAATIERLK KVGYITMQGK
RITVTQKGRT AIELIRLAGV ELLTSPEMTG HWERRLHQIS KGEAAGEKFM ESVKKFTISI
IEKVRTQRKA DASRFESPEE DKTKGKSKRS SGSSPRSTTD SSRSRPSSGS TPPSGGLQPL
APCPRDGCGG QIIEGRKGYG CSHFKQGCGF VIWKEFSGKK ISHAMLNTLL EKGHTQLLTF
KDPEGEYKAR ISLVDRISGK LEIDRE
//
