ID   A0A1G7H177_9BACT        Unreviewed;      1056 AA.
AC   A0A1G7H177;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SDE94168.1};
GN   ORFNames=SAMN05444167_0878 {ECO:0000313|EMBL:SDE94168.1};
OS   Terriglobus roseus.
OC   Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC   Terriglobus.
OX   NCBI_TaxID=392734 {ECO:0000313|EMBL:SDE94168.1, ECO:0000313|Proteomes:UP000182427};
RN   [1] {ECO:0000313|EMBL:SDE94168.1, ECO:0000313|Proteomes:UP000182427}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GAS232 {ECO:0000313|EMBL:SDE94168.1,
RC   ECO:0000313|Proteomes:UP000182427};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; LT629690; SDE94168.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G7H177; -.
DR   OrthoDB; 9757876at2; -.
DR   Proteomes; UP000182427; Chromosome i.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000182427};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        342..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        399..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        445..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        489..512
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        542..562
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        878..897
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        904..924
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        930..954
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        974..995
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1007..1033
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1056 AA;  114789 MW;  73A2099A61F8A3E8 CRC64;
     MLQRLIAGAL RQRLILVVVS LVLLGFGLNA AKHLSVDAFP DVANVQVQIA TEATGKSPEE
     VERFVTVPIE IAMTGLPGMT DMRSLNKPGL SLITLVFTDE SDLFRERQMI SERLAELRDR
     MPEGVTPVLG PITNALGEVY QYTLEVPGEA ESKHVLTQEE LIERRTLQDW VVRPLLRSIS
     GVAEINSTGG FVKQYETLVD PQKLHYYNLT IHDVSSALSH NNANEGGGVL PQHAEQYLIR
     SVGLIRDLDD IRNIVLKESG GTPVYIRDVA DVRIGTEVRY GAMMKNGYSE AVGGVVLMTS
     GGNAKEIVSR VKERVAEINA KHMIPDGLQI VPYYDRSQLV DAAIHTVTEV LGEGIVLVVV
     ILFLFLGDLR SSLIVSANLV LTPLLTFLVM NHFHISANLM SLGGLAIAIG LMVDGSVVVV
     ENVFGTLSHA SHSGQLTSRR GKCDMVLRAV GDVATPTLFG VTIIILVFLP LMTLEGMEGK
     MFAPLAYTIA IALAISLLLS LTLSPVLCTY LLKGGKEDDT WLVRILRRPY QAVLHWATSH
     RAWMIGGVVV LFIGALCLFP FLGTSFIPEM QEGTLSPNAD RVPNISLDES LRMEKQMQAL
     MLKVPGVENV VSRVGRGESP ADPAGPNEAD VLASLTPFDE RPRGMTQDKI AEQIREKLAA
     LPGINLVMSQ PISDRVDEMV SGVRADVAVM LYGDDLGLLV KKAGDIARVA SSITGTQDTR
     VDRVGGQQYL TIQINRGAIA RYGLNASDVN EVIETAIAGK SATQIYEGER RFSGVVRLPA
     RLRDSVEDIR ELQINSPDGP RIPLKELADV KVMEGPALIN RSMGKRRIVV GVNVQDRDLG
     GYVKELQQKV EQQVPLPAGY FIEWGGQFHN MERALHHLMI IVPITIAAIF FLLFVLFKSV
     RYAALIITVL PLASIGGIVG LFISGEYLSV PASVGFIALW GIAVLNGVVL VSYIKKLRLD
     GKSQAEAIRE GTALRFRPVM MTATVAALGL VPFLFATGPG SEIQRPLAIV VIGGLVTSTA
     LTLLLLPVVY PLFEGKDVPL LAEDEDDVQN PVPYVS
//