ID A0A1G7H2D9_9BACT Unreviewed; 934 AA.
AC A0A1G7H2D9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311, ECO:0000256|RuleBase:RU004460};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU004460};
GN Name=polA {ECO:0000256|RuleBase:RU004460};
GN ORFNames=SAMN05444167_0894 {ECO:0000313|EMBL:SDE94602.1};
OS Terriglobus roseus.
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Terriglobus.
OX NCBI_TaxID=392734 {ECO:0000313|EMBL:SDE94602.1, ECO:0000313|Proteomes:UP000182427};
RN [1] {ECO:0000313|EMBL:SDE94602.1, ECO:0000313|Proteomes:UP000182427}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAS232 {ECO:0000313|EMBL:SDE94602.1,
RC ECO:0000313|Proteomes:UP000182427};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU004460};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
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DR EMBL; LT629690; SDE94602.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7H2D9; -.
DR OrthoDB; 9806424at2; -.
DR Proteomes; UP000182427; Chromosome i.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR CDD; cd06140; DNA_polA_I_Bacillus_like_exo; 1.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR018320; DNA_polymerase_1.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00593; pola; 1.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU004460};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU004460};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU004460};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU004460}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004460};
KW Reference proteome {ECO:0000313|Proteomes:UP000182427};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT DOMAIN 5..291
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 692..898
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 934 AA; 103514 MW; EFA64E5BC4EEAD89 CRC64;
MPNETKPPVY LLDTMAFIFR AYHAMQRSRP MSTRTGVPTA ATYVFINMIN KLRQDFHPHY
LAAIYEGGAP VHRNEAAAQM KTIKKFNIKT QQFDEVDYGG YKATRTETPP DLTQQQPYIR
RALEAFGIPI LAHEGFEADD VIGTLSQRLS EQGHPVYIVS SDKDMMQLVT DSVHILNPTK
DNLILDPAKV EEVLGVPPQR VIDVMALRGD SIDNIPGAPG IGDKGSVELI QQFGSVEAAL
DAARDTPDSI KGKRQRESLQ NNRDTVMLSK ELVTIHCNLP VDYSLEAMST ATEPNLADLR
ALYTELEFTT LLKDLPAPEA QKIDYILNPT AQDITELLAA SDTLAIFFPE DAQAIAEESG
AETELDTESP AEDPIATNMD LFAAMTTPVE TKPFAPPQTE PLPVGLATTA NKAILLDLNT
DIAAPIREAL KNNKIPKAVH DLKAVLRTCE RAKIEIKNVR DDVMLYSYLI NPTHGSHKLS
DVAARFNDRA LTQVEKKQTP PPHILPEAAS AVFQLATTLR PQVEEAELNK TYEDIDLPLV
PVLLHMEQAG CRIDTDLLRA QNTRLAVAMD DLAARIHTLA GRTFNINSPK QLGEVLFNEM
NLPKPLKYGK GKVVSTAQDV LEELSEQHEA PRLVLEYRQL AKLRSNYTEQ LPLLVDTDSR
VHTTFNQVGT ATGRLSSTNP NLQNIPVRTE LGREIRAAFT AQPGNVILSA DYSQIELRLM
AHFSQDPLLL NAYRTNIDIH TLTASEVFGV DPATMSKETR NRAKAVNFGI VYGISPFGLA
AQLGIDQKEA RTYIETYFDR YKGVQTFITE LLEQTRNTGK VTTLFGRTRP IPDIQSRNPN
MRGFAERTAV NTPLQGTAAD MIKVAMLHID KALTAGNYKT RMTLQVHDEL LFDAPKEEAE
AVAALVKKEM ESVIQLSIPI VAEVGQGPNW RDAK
//