ID A0A1G7HJF8_9DEIN Unreviewed; 416 AA.
AC A0A1G7HJF8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN04488243_1202 {ECO:0000313|EMBL:SDF00493.1};
OS Thermus arciformis.
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=482827 {ECO:0000313|EMBL:SDF00493.1, ECO:0000313|Proteomes:UP000199446};
RN [1] {ECO:0000313|EMBL:SDF00493.1, ECO:0000313|Proteomes:UP000199446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6992 {ECO:0000313|EMBL:SDF00493.1,
RC ECO:0000313|Proteomes:UP000199446};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; FNBC01000020; SDF00493.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7HJF8; -.
DR STRING; 482827.SAMN04488243_1202; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000199446; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.90.220.10; Adenine-n6-DNA-methyltransferase Taqi, Chain A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR021188; N6_DNA_MeTrfase_TaqI.
DR InterPro; IPR023135; N6_DNA_MeTrfase_TaqI_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PIRSF; PIRSF037236; Ade-sp_methyltransferase_TaqI; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SDF00493.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SDF00493.1}.
FT DOMAIN 97..203
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT DOMAIN 289..403
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 416 AA; 47080 MW; BB576CB7855103F4 CRC64;
MLFPPSLPPT PSGRSLGRVE TPPELVRFMV GLAEAPKGGR VLEPACADGP FLRAFREAHG
TGYRFVGVEI DPNALDLPPW AEGVVADFLL WEPGEAFDLI LGNPPYGIVG EASKYPIHVL
KEAKGLYKKA LSTWKGKYNL YGAFIEKSVR LLRAGGTLVF VVPATWLVLD DFSLLRAFLA
REGRTEVYYL GEVFPGRKVS AVVLRFRKGG RGLALWDTRK EGEGFIPFLW SEDPEWNGEI
IRFETGWTRE MEASGTPLGS LFHIRFAARS PEFKKHPAVR REPGAGLVPV LTGRNLKPGW
IDYESNYSGL WMPKERAKEL RDFYATPHLV VAHTKGTKVV GAWDEKAYPW REEFHLLPKE
GVKLDLLFLV EWLNSEKMQV YVRTLYRDFV PHLTLRMLER LPVRRENGFR TNPSSS
//
