ID A0A1G7IRN4_9BACL Unreviewed; 368 AA.
AC A0A1G7IRN4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=SAMN04488542_106108 {ECO:0000313|EMBL:SDF15214.1};
OS Fontibacillus panacisegetis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Fontibacillus.
OX NCBI_TaxID=670482 {ECO:0000313|EMBL:SDF15214.1, ECO:0000313|Proteomes:UP000198972};
RN [1] {ECO:0000313|EMBL:SDF15214.1, ECO:0000313|Proteomes:UP000198972}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28129 {ECO:0000313|EMBL:SDF15214.1,
RC ECO:0000313|Proteomes:UP000198972};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
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DR EMBL; FNBG01000006; SDF15214.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7IRN4; -.
DR STRING; 670482.SAMN04488542_106108; -.
DR Proteomes; UP000198972; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Carboxypeptidase {ECO:0000313|EMBL:SDF15214.1};
KW Hydrolase {ECO:0000313|EMBL:SDF15214.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:SDF15214.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198972};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..288
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 368 AA; 41832 MW; A3771D0EFB3CDAB0 CRC64;
MIVLYIFMGI FALFLLLVLL LIVLKKINDK KTEQDVLKFI VKNPDRASFY VMENGKILVN
TGAEIKRPLA SVVKIMVLAE FAEQVSAGMI DVAEEVHLSS LNRFYIPKTD GGAHSKWLDN
LKEQGLDLEA KCTLKEVARG MILYSSNANT EFLIEKLGLE AINHRIQEWG LEQHDLIYPL
SSSMLIPSYL MDTLDLSKKQ VAAYIADISY SDYANKASEI FNLLQSDEEG KWIDQLNRQE
TSGLKLQELW SAKLPGSTVQ EYAHMLADIQ EGKLLSEQAQ PIFHELMEIK LKNPEPFIYV
GQKGGSSISI INQVIYSEDM NGNKIQFALF IHDPFGADRI WLNKKFDLFI NKFFKDEPFK
QQVVEALA
//
