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Database: UniProt
Entry: A0A1G7IVN0_9RHOB
LinkDB: A0A1G7IVN0_9RHOB
Original site: A0A1G7IVN0_9RHOB 
ID   A0A1G7IVN0_9RHOB        Unreviewed;       422 AA.
AC   A0A1G7IVN0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   13-FEB-2019, entry version 9.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=SAMN04488567_3540 {ECO:0000313|EMBL:SDF16624.1};
OS   Limimaricola pyoseonensis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Limimaricola.
OX   NCBI_TaxID=521013 {ECO:0000313|EMBL:SDF16624.1, ECO:0000313|Proteomes:UP000198922};
RN   [1] {ECO:0000313|EMBL:SDF16624.1, ECO:0000313|Proteomes:UP000198922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21424 {ECO:0000313|EMBL:SDF16624.1,
RC   ECO:0000313|Proteomes:UP000198922};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; FNAT01000008; SDF16624.1; -; Genomic_DNA.
DR   BioCyc; GCF_900102015:BLT43_RS15115-MONOMER; -.
DR   Proteomes; UP000198922; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000198922};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124}.
FT   DOMAIN      320    405       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    269    269       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     126    126       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     162    162       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     272    272       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     334    334       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   422 AA;  44090 MW;  30AD81F6FACDE6D8 CRC64;
     MKVVVFGLGY VGATAVGCIA RCGHEVVGID VNRDKVATLN AGRSPILEPG LEPMIAAAVE
     EGRLTAQGDI GDALDRADLA LVCVGTPSAA DGAHNMGYIA EVSRQIAQAV ARRPAGPPLA
     VVYRSTIRPG TTAQLIRPIF EGVLGAGAPG VDLVYNPEFL REGSAVADYF APPKIVLGTE
     SAAPVPAMEA LNDGIDAPVF RTGFGEAEIT KFVDNSWHAV KVAFANEVGR VCLSAGLSAT
     RVHEIFVSDT KLNISACYTR PGGAFGGSCL PKDVRALQHL GADIGANLPL IDSLLRSNEA
     HKNALFAAAT RGLAPGASLL MVGLAFKAGT DDLRESPNVD LARKLLAAGY ALDIYDPAIR
     ADMLLGANLG YAYSQLPQLE RLLIPRGSAE ARRYDRILLS NATAREVRLP PGAETFDCGA
     LA
//
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