ID A0A1G7JAR9_9BACT Unreviewed; 576 AA.
AC A0A1G7JAR9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05216518_10487 {ECO:0000313|EMBL:SDF21978.1};
OS Bacteroidales bacterium KHT7.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales.
OX NCBI_TaxID=1855373 {ECO:0000313|EMBL:SDF21978.1, ECO:0000313|Proteomes:UP000198526};
RN [1] {ECO:0000313|EMBL:SDF21978.1, ECO:0000313|Proteomes:UP000198526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KHT7 {ECO:0000313|EMBL:SDF21978.1,
RC ECO:0000313|Proteomes:UP000198526};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FNBQ01000004; SDF21978.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7JAR9; -.
DR STRING; 1855373.SAMN05216518_10487; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000198526; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000198526}.
FT DOMAIN 9..147
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 155..444
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 576 AA; 65391 MW; 33691E041C290933 CRC64;
MTDIELKNLK DRLWHSADML RAGAHLAANK YGQPILGLIF LRYADVLFKQ HKAEIDAEYN
QYKGTRMERD YKDVAVEKCG FFLPECAYFD YINDAPDDAN KALLVKNAME AIESENPRMD
GVLPKEVYGQ LVPEEEPELL SRIVRVFKDI PEDISIDLFG QIYEYFLGNF ALAEGQGGGA
FYTPATVVQY MVEVLQPTTG DKKFLDPACG SGGMFVQAAR YMHRHNATND QMMQFRCYGV
EKEPDTVKLA KMNLLLNNVR GDITEANSFY SDPYSAFGQF DYVMANPPFN VDEVVLEKVI
DDARFNTYGV PRNKTKSGKK SSDKRETVPN ANYLWIGYFA TALNANGKAA LVMANSASDA
SGSELEIRKK MIEDGIISQM VTLPSNMFST VTLPATLWFF NKKRTNRDEI LFIDARNVFT
QVDRAHRKFS EEQIKNLGII SRLYEGDSDA FWALVDEYKK EKQNAPSTSD DKEVKTKDYW
QEQIDWLLER WSDGKYQDVI GLCKVAKLEG EDGIIDNDYS LNAGRYVGVV IEDDGMTEDE
FKETMKGLNA DFSTLNVEAE ELAKQISENL KELWGE
//
