ID A0A1G7JX69_9EURY Unreviewed; 536 AA.
AC A0A1G7JX69;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Predicted spermidine synthase with an N-terminal membrane domain {ECO:0000313|EMBL:SDF29557.1};
GN ORFNames=SAMN05216218_10593 {ECO:0000313|EMBL:SDF29557.1};
OS Halorientalis regularis.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Halorientalis.
OX NCBI_TaxID=660518 {ECO:0000313|EMBL:SDF29557.1, ECO:0000313|Proteomes:UP000199076};
RN [1] {ECO:0000313|EMBL:SDF29557.1, ECO:0000313|Proteomes:UP000199076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBRC-M 10760 {ECO:0000313|EMBL:SDF29557.1,
RC ECO:0000313|Proteomes:UP000199076};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867}.
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DR EMBL; FNBK01000005; SDF29557.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7JX69; -.
DR STRING; 660518.SAMN05216218_10593; -.
DR OrthoDB; 10538at2157; -.
DR Proteomes; UP000199076; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd06174; MFS; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR43317:SF9; POLYAMINE AMINOPROPYLTRANSFERASE 2; 1.
DR PANTHER; PTHR43317; THERMOSPERMINE SYNTHASE ACAULIS5; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..466
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 379
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 536 AA; 57565 MW; 454AB00C0A397B29 CRC64;
MSALSRRFSG GVSSPELAVF VSGVVSMGLE ILAGRMVAPQ FGSSIYTWGS IIGVFLAALS
LGYYQGGKRA SRRATEERLV RVLLATGAFV AVLILAGDLL LAGLSGFPLP PRFASLPAVT
VLFGPPTYLL GFISPYGAEL SRKESTGAAS GHVYAVGTIG SIVGAFGATF LLIPSLSVSL
IGLVFGLLLV GTSLVILAPS FPRRTVLATL VVGVLLVGAV AVPSAGYSVR GETVYQTQTP
YQELVVADLG DTRTLYLDGQ PHSAMDLEYP NRHVFEYTRY FHVPFLLGDW RNETTASAPH
QSGDIDRVLF IGGGGFTGPK RFVNDYNVTV DVVEIDPEVI RVAKEYFGVE EGPRLNIYNA
EGREFLRTTD RTYDLIVLDA YKKDKVPFQL TTREFMQLTA DRLDEDGILL ANIISAPTGP
ASQFYRAEYK TMNRVYPQVY SFPTSGGSVV QNIEVVATKS DARVSQAQLE ARDERRDIGI
GLSTELADYQ AEVDTGGVPV LTDDRAPVNA LLEPMAGRRY VVSQTGPGGN VTTGTG
//
