ID   A0A1G7NR46_9BURK        Unreviewed;       428 AA.
AC   A0A1G7NR46;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Sodium/proton antiporter, CPA1 family (TC 2.A.36) {ECO:0000313|EMBL:SDF76456.1};
GN   ORFNames=SAMN05216320_1011237 {ECO:0000313|EMBL:SDF76456.1};
OS   Duganella sp. OV458.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Oxalobacteraceae; Telluria group; Duganella.
OX   NCBI_TaxID=1855290 {ECO:0000313|EMBL:SDF76456.1, ECO:0000313|Proteomes:UP000199454};
RN   [1] {ECO:0000313|EMBL:SDF76456.1, ECO:0000313|Proteomes:UP000199454}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OV458 {ECO:0000313|EMBL:SDF76456.1,
RC   ECO:0000313|Proteomes:UP000199454};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FNCD01000001; SDF76456.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G7NR46; -.
DR   OrthoDB; 9810860at2; -.
DR   Proteomes; UP000199454; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR   PANTHER; PTHR32507:SF8; TRANSPORTER-RELATED; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        30..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        63..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        94..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        371..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        402..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          13..268
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   DOMAIN          342..425
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   428 AA;  45911 MW;  1BBDDC7C85933608 CRC64;
     MNTNQWFLLV GLLMLARGLA ATTISRSPFT SAIVYLAVGL VLGPSGLNFF NFDPAKESGL
     LEMLAEIALL ISLFSAGIKM PVPFTLSRWN APLRLAWLSM ALTVGLIALF CWYVLHLPIG
     AAVLLGGILA PTDPVLATDV QVRHSGDKDE LRFNLTCEAG MNDGSAFPFV LLGLGMLHMG
     EAGEHHWRWL LVDVIWATGA AVVVGIVAGA GLARLGWRLR VLEPRHEIMD DLVGLGLIAI
     VFSITSLMKA SGFLAVFFAA VALRQTELKL AGAPKDGQGL REPELAKSEV AQASDSKEAP
     LVVSNEALVF KEHLERLSEL TLVLLLGGMI SLRELPYETI GVAAFLFLVA RPLAVYVGLI
     GSGTNKRMRA LIGWFGVRGI GSIFYLVYAI EAGLPPNLAK QLTGIALGVI MLSILVHGFS
     VKPLIDTK
//