ID A0A1G7NYQ3_9SPHI Unreviewed; 2577 AA.
AC A0A1G7NYQ3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=PfaB family protein {ECO:0000313|EMBL:SDF78987.1};
GN ORFNames=SAMN05216464_13110 {ECO:0000313|EMBL:SDF78987.1};
OS Mucilaginibacter pineti.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Mucilaginibacter.
OX NCBI_TaxID=1391627 {ECO:0000313|EMBL:SDF78987.1, ECO:0000313|Proteomes:UP000199072};
RN [1] {ECO:0000313|EMBL:SDF78987.1, ECO:0000313|Proteomes:UP000199072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=47C3B {ECO:0000313|EMBL:SDF78987.1,
RC ECO:0000313|Proteomes:UP000199072};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thioester dehydratase family. FabA
CC subfamily. {ECO:0000256|ARBA:ARBA00006714}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
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DR EMBL; FNAI01000031; SDF78987.1; -; Genomic_DNA.
DR STRING; 1391627.SAMN05216464_13110; -.
DR OrthoDB; 9778690at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000199072; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008693; F:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:InterPro.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0034017; F:trans-2-decenoyl-acyl-carrier-protein isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01287; FabA; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 4.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010083; FabA.
DR InterPro; IPR013114; FabA_FabZ.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF07977; FabA; 3.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000199072};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 3..435
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2577 AA; 283087 MW; C18D51C705BE3318 CRC64;
MKFEEIAIIG EGCVLPGCFN PAQLWETVLH NRVNISNAPD NDWRVPMVEV LHRQNNSDMA
NRAWHDKGGY IKGFEQHFDA GDYNLDTRLV EELDPLFKWS FYAAKQALTD AGITNNDLLQ
SAGLIMGNLS YPTRSFSRLF EEFQLKQFFP DIKGKTSVND LNRFCSGLPA MLTAKAIGLQ
GEAFALDAAC ASSLYALKLA CDRLHDHRAD MMLVGGVCAA DQLFLHTGFT ALNALSPSGQ
SRPFNAAADG LIPAEGAAFI VVRRLADAIR DGNKIRAVIK GIGLSNDGRS GGFLSPSTDG
QVRSIKQALA LADIRPAEVS YLECHATGTS GGDAIELASI KAVYGDNPDL VLGSLKANLG
HSITASGVAG ILKVIAAFKH KRIPAMLNHL PLAPVVAASG YPVLSADKPW LGNKKIAGIS
NFGFGGNNAH LILAEWDRQP VAVAVQNKKN GVAIIGIAIR SDRFSGTSQV FNYLINDVVS
PPASELEFEA RALNFPPNDL KQTLGQQLLL LSTVQDLLTT CGPIDAQQSG VFIGMGVDAE
INRYGLGKRL ASLLKEHSLG VSAEALAETE ASIAAPLTPA SVLGTMPNIP ANRISNQFNL
EGPGFTVSAE ELSGLKALRI AVDAIRNGEL KSAIAGAVDL SNEELHGDVL KKITGFEGDT
TDLAVALLLK DHEQALAAGD TIFAIISDKG GEEENLSIDP DWVNKKLGYT HAASGLLSVA
IAALFTRNRL RIDPTGTGLL PIPEPKNGLA YQIVVHSYFG GSETFRLVAQ PVGSISGRAI
NFVKIYCYAG SAVTSLREAV LAGKINGKGT HKLTIVCSED EIAQNSQLAV HLLDKPDLRE
GWLNDVIFYS SEAVDGKIAF AFTGAASAYP RMGQHLLQEF PALSASLAPS CSNPGFAANW
IYENDSGKAD LPFYQLAGSS FLCQIHAAFS MKILGIKPDI ALGLSSGETN SMFAMGVWDD
MDALLAEIEA SDLYTKALGV DFAAVRTHWN LAENEPVNWE SWRAIATVAE VEALLATETR
AYLTIVNTDT DCVFGGDAEA CARIIDKIGK HRVMQLHHDI AVHCEVVNPY EAEWRRLHTR
NSKPIKGIAF YSNYLNDIYE TTTENVADAL TGQAVKPIHF PRIIEKAWAN GVRIFIEHGP
RNSLSAAIST ILQGKDHVCV SFDRAGKNSL LQAAKVAAQL WAYGVAVDLS CFKPGPIHNA
KNPITLSFPL RMPAIKRLPL AATVMPQPPM SAIKKMRPAP TLALTGQALP KESNVQPFVK
PVLTTKAEVP VAESADHLQT QATGDPVLQL LLSQHKAMLE AHQLFLQTAS AGYEQFSHMM
NGMAASLGSV QEAVKEDRLI AAALTTRETL PEYLATHEVV PDETTIDAHL SSRVREISTE
VALVPVGLPG PKFSRKQLEV LSSGKISTIF GPLFEQQDKY DIQVRMPEPP LLLCDRVTGI
QGEPGTLSLG TIWTETDVKA DSWYLHNNRM PPGIFIEAGQ ADLLLISWLG IDFENKGERA
YRLLGCELTF HGGLPKPGET LQYEIHVDGY AKSGETTLFF FHYNCHVDGK LRISVSGGQA
GFFSKQELTE SKGVIWNPEE ATYDAFDTTI LANATKKNNF TIDEVIAYTE GDMASCFGTQ
FDFTQTHSRS PRSQEGYRNF IKTVTDFDLK GGPSKLGYLR SETMVSPDDW FFKGHFKNDE
CMPGTLMADA CLQMMAFYMV GAGLAVDKDG WRFEPVTDEK YKFVCRGQVT PASVKVTYEL
FIAGITLDPV PTMHAHVLTT VDGTKAFLCE NLGLQLIPDW PINTLLAELG LSDANLPSAD
YKGFKLDHLS LLNCALGNPS DAFGEDFNHY TGLIRSPRLP RPPYHFMTRI VSLHALPGGY
KDKPSVTAEY DISQSVWYFN ENGRATMPYA VLMEVALQPC GWLSTFTCQY DIKGKDLLFR
NLDGEAIQHR EITPADKTIL THTELSGVSI MGEIIIVKFE VTSTSFGEPV FTMKTVFGFF
DPESMKTQKG LPQSAQEQEN YHAAANYETS LHSFPAKFFL NSSARLPASK LLMIDRLVRF
DPIGGQYGKG YIRAQKDVNK NEWFFKAHFF QDPVQPGSLG IEAILQVMQA YLLDQGLHLG
ITDPVFEPVL IKETTEWHYR GQVTPENELI SADFDVESVI KEENYVILTG YGRLWVDGLK
IYSAPRIGMK VYAASTPVSR KFLLSPMQRI IYGQYNAPGN EPWIYHTQFS YHLQIKQLDK
TLFERAVSLV LSRHPLFKTV FFKEDGLVMQ GINADIKPNL FIRDLPGDVT EQVLQIQNQL
LADRKAPFDV NQTSAALYRV YLLHRNRNEL QFVLTIHHAI WDGWSLAVFM KEILDLYTML
KTNHAYLPLP ATYSFANYLD KNVLPAKNIT KKGSSPQFKH DSDGQAYLPV QTTLGAKLAI
AIKKVAKERK VPLKALFLAA FAHLLSDDNG TVIIDVVTNG RDLALTDPLG TFGLLWALMP
VHLSARENDQ EYLQHVQQQL AAVEKKALIT DYTDSLAVFN YINFEGANIL SDSPDVQFME
TGGLDRFHHP LHLLVGKSPF TGEFSLVWNY DSRLYKLEEI EQLMQQYVQI LAAYAIP
//