ID A0A1G7P3S2_9GAMM Unreviewed; 867 AA.
AC A0A1G7P3S2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN05216571_102102 {ECO:0000313|EMBL:SDF80903.1};
OS Halomonas taeanensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=284577 {ECO:0000313|EMBL:SDF80903.1, ECO:0000313|Proteomes:UP000198641};
RN [1] {ECO:0000313|EMBL:SDF80903.1, ECO:0000313|Proteomes:UP000198641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BH539 {ECO:0000313|EMBL:SDF80903.1,
RC ECO:0000313|Proteomes:UP000198641};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FNCI01000002; SDF80903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7P3S2; -.
DR STRING; 284577.SAMN05216571_102102; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000198641; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198641}.
FT DOMAIN 689..705
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 804..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 615..622
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 867 AA; 94853 MW; D17485FA55EFB7E5 CRC64;
MTQASAQHTP MMSQFLKIKR EHPEVLLFYR MGDFYELFFD DAKRAAALLD ITLTQRGQSA
GKPIPMAGVP YHSAEGYLAR LVKAGESVAI CEQIGDPATS KGPVERKVVR IVTPGTLYDE
ALLDASRDNL VLAAYPRGET WGMAWLELSS GRFSVLEVEG EAEMLAEVQR LDPAELLIAD
SQDLPPSLAE RRGLRRQSDW LFDLESATRT LCDQFAVQDL RGFGCAHLEA AMTAAGVLID
YARDTQRSQL PHVTAIGVEN RDDAVVIDAA SRRNLEIDTN LGGSGDNTLA SVLDTTATAM
GSRLMKRWLN RPLHDRPRVL ARQAAVALLL DDEAFLPLRD DLKAIGDVER ILARVALRSA
RPRDLARLRD ALNALPGLEA SLSGFDEGTA LDELKRHIRP YPALAETLTR ALVENPPVVI
RDGGVIASGY DEELDEQRGL AENAGDYLIQ LETRERERTG LAGLKVGYNR VHGYYIEIPR
AQAREAPADY IRRQTLKNAE RFIIPELKEF EDKALSAKSR ALGREKLLYE ALLDTLGAEL
DALQQSGRAL ASLDVLASFA ERAQALDFVR PTLTEAPGIN IQGGRHPVVE HVSEAPFVPN
DLALDDSRRM LVITGPNMGG KSTYMRQAAL ITLMAHTGSF VPADAAEIGP VDRIFTRIGS
SDDLAGGRST FMVEMTETAN ILHNASDKSL VLMDEIGRGT STFDGLSLAW ASAEHLTRSR
AFTLFATHYF EMTALPDQAP GVANVHLTAA EHKDGIVFMH RVEDGPASQS YGLQVAQLAG
VPQHVIARAR EKLALLEQQE IDQGQRQTPL ADPAADTGAS AAPSAPRQDD LFASTPHPLL
DELSSLDVDG LSPRQALELL YTWREKV
//
