ID A0A1G7P742_9GAMM Unreviewed; 472 AA.
AC A0A1G7P742;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN ORFNames=SAMN05216571_102161 {ECO:0000313|EMBL:SDF82122.1};
OS Halomonas taeanensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=284577 {ECO:0000313|EMBL:SDF82122.1, ECO:0000313|Proteomes:UP000198641};
RN [1] {ECO:0000313|EMBL:SDF82122.1, ECO:0000313|Proteomes:UP000198641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BH539 {ECO:0000313|EMBL:SDF82122.1,
RC ECO:0000313|Proteomes:UP000198641};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-
CC insoluble oligonucleotides, which are then degraded further into small
CC acid-soluble oligonucleotides. {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-
CC direction to yield nucleoside 5'-phosphates.; EC=3.1.11.6;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355};
CC -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00378}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC ECO:0000256|RuleBase:RU004355}.
CC -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC Rule:MF_00378, ECO:0000256|RuleBase:RU004355}.
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DR EMBL; FNCI01000002; SDF82122.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7P742; -.
DR STRING; 284577.SAMN05216571_102161; -.
DR OrthoDB; 9802795at2; -.
DR Proteomes; UP000198641; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04489; ExoVII_LU_OBF; 1.
DR Gene3D; 2.40.50.1010; -; 1.
DR HAMAP; MF_00378; Exonuc_7_L; 1.
DR InterPro; IPR003753; Exonuc_VII_L.
DR InterPro; IPR020579; Exonuc_VII_lsu_C.
DR InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR NCBIfam; TIGR00237; xseA; 1.
DR PANTHER; PTHR30008; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR PANTHER; PTHR30008:SF0; EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT; 1.
DR Pfam; PF02601; Exonuc_VII_L; 1.
DR Pfam; PF13742; tRNA_anti_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00378};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_00378};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00378};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00378};
KW Reference proteome {ECO:0000313|Proteomes:UP000198641}.
FT DOMAIN 9..101
FT /note="OB-fold nucleic acid binding"
FT /evidence="ECO:0000259|Pfam:PF13742"
FT DOMAIN 128..439
FT /note="Exonuclease VII large subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02601"
FT REGION 440..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 275..303
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 472 AA; 52383 MW; 2B4CA40216CA58DD CRC64;
MPQADTPPLS VSELNRRARL MLERDFGDCW VEGELSGVAR PASGHVYFTL KDERAQLKCA
LFRNRARFVG SPLNDGDRVR LRGKVSIFEP RGDYQMIVEA VQPTGQGDLL AAFERLKHQL
GAEGVFANAR PLPCPPRHLL VLTSPTGAAI RDVLAVLAAR WPLSRVSVLP VPVQGKEAAP
AMIRALALAN RDARFDPERD AILVTRGGGS LEDLWAFNDE HLARAIFHSR LPVLSAVGHE
TDVTLSDFAA DARSPTPSAA AERLVPDQTA LRQRLDSALS RLARAQRSRL DAETQRLDHL
RARLRHPGER LAQQRAHLGQ LEGRLQRAMQ SRLVEARTRQ RHAGARLKAF DPRQQLDSAR
QRLAQADNRL MAALPRQLAE HRQRLSSLVR ELQAVSPLAV LGRGYSILAD DEGRVIRRSQ
DTQPGQQLTA RLGEGRLKVE VKRRFKSAPA PDQAATQAKD QAKDPQRQNE AD
//
