ID A0A1G7T2L9_9BURK Unreviewed; 718 AA.
AC A0A1G7T2L9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=SAMN05216320_103532 {ECO:0000313|EMBL:SDG29284.1};
OS Duganella sp. OV458.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Duganella.
OX NCBI_TaxID=1855290 {ECO:0000313|EMBL:SDG29284.1, ECO:0000313|Proteomes:UP000199454};
RN [1] {ECO:0000313|EMBL:SDG29284.1, ECO:0000313|Proteomes:UP000199454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OV458 {ECO:0000313|EMBL:SDG29284.1,
RC ECO:0000313|Proteomes:UP000199454};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNCD01000003; SDG29284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G7T2L9; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000199454; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 214..332
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 527..674
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 376..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 76063 MW; 9B9E2FCB1AC3798C CRC64;
MNAPDLRPPR PIQALPDQLI SQIAAGEVVE RPSAVVKELL ENALDAGSTQ VTVRLEEGGV
KRICITDNGR GIPHDQMQLA LARHATSKIA SLDDLEHVGT LGFRGEALAS IASVAQVTIT
SRTADAAHAW EIEGSHNATP TPSSGALGTT IDVKDLYYNT PARRKFLKSE QTEYGHCAEV
VRRIALARPD VSFSLTHNGR TVEHWNTSEI ARRSAQILGD GFADARLPVD ETIGPLRLHG
YVGLPTASKA RADGQFFYVN GRFVRDKVLV HAVKAAYQDV LHGDRFPSYV LSLDMDPALV
DVNVHPSKIE VRFRDGRAVH QCVFHAVQRA LAQTSATAHG SVPSPLPAAD TLATTPMWRG
EQTSFGPLLA PDYAPTFSPS PFGPRGADAT GAADGSPAGY RAHSGYGAAD GTTGGGFDGA
AGGGFSGAAG DGSSGPSGNG FGGPVGGSFG GPSGNGYAGG NGAAGYAGPR FDANGGVAQS
TERYGAMFRD PDRPGDRSAA DMTLPQASSF TVSAAAMAQE EFPLGFALAQ LHGIYILAQN
AKGLVLVDMH AAHERILYEQ LKTALDSRVA GEEMQVQPLL IPITFYADAV EVGTAEEHQD
TLRTLGFDIA VLSPTTLAVR SVPVLLKNAD AQTLARDVLR DVREFGGSRV LIERQNELLG
TLACHTAVRA NRILAVQEMN ALLRQMEITE RADQCNHGRP TWVQVEIGAL DKLFLRGQ
//
