ID   A0A1G7WLI8_9ACTN        Unreviewed;       593 AA.
AC   A0A1G7WLI8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:SDG72744.1};
GN   ORFNames=SAMN05660324_3403 {ECO:0000313|EMBL:SDG72744.1};
OS   Klenkia brasiliensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Klenkia.
OX   NCBI_TaxID=333142 {ECO:0000313|EMBL:SDG72744.1, ECO:0000313|Proteomes:UP000198863};
RN   [1] {ECO:0000313|EMBL:SDG72744.1, ECO:0000313|Proteomes:UP000198863}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44526 {ECO:0000313|EMBL:SDG72744.1,
RC   ECO:0000313|Proteomes:UP000198863};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; FNCF01000005; SDG72744.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G7WLI8; -.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000198863; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 2.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   4: Predicted;
FT   DOMAIN          7..185
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          188..284
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          313..491
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          494..589
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   593 AA;  63023 MW;  E6D7FA9BEEE97852 CRC64;
     MARELSQVGV VGLGTMGAGI TEVLARAGLD VTAVEVSDEA LERGRGHLEQ STDKAVQRGK
     LDAAERDVVL SRVRWSTSLD DLAEVELVIE AVPERMELKT EVLARLDKIC PPDTILATNT
     SSLSVTELSV ATGRPSKVIG MHFFNPAPVM KLVEVISTVV TEPSVIADVE ALAERLGKTD
     VTVGDKAGFI ANALLFGYLN HAVSMYEARY ASREDIDAAM RLGCGLPMGP LALMDLIGID
     TAYEILDTMY KQSRDRLHAP SPIIKQLMTA GLLGRKTGRG FYTYAGRDSA EVVPDAQTPT
     PGGAAEGARP VRTVGLAGSG TMATGMIEVF AKAGYDTLFV ARTPDKVEGV LAAIGKSLDK
     QVTRGKLDED GKAAVLARLT GTTDRADLAD VDLVVEAVVE SLAVKQELFA ELGRICKPGA
     VLATTTSSLP VIECAQASGR PADVVGLHFF NPATVMKLVE VVSTVATADD VAATAHAVCQ
     QLGKHAVSCT DRSGFIVNAL LFPYLNDAVR MLQAHYATAD DIDAAMKVGC GYPMGPFELL
     DTVGLDVSLA IERELYTEFR EPGFAPAPLL EHLVTAGYLG RKTGRGFREH ARR
//