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Database: UniProt
Entry: A0A1G7XQL1_9RHOB
LinkDB: A0A1G7XQL1_9RHOB
Original site: A0A1G7XQL1_9RHOB 
ID   A0A1G7XQL1_9RHOB        Unreviewed;       698 AA.
AC   A0A1G7XQL1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 9.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SDG86489.1};
GN   ORFNames=SAMN04489759_11328 {ECO:0000313|EMBL:SDG86489.1};
OS   Sulfitobacter delicatus.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Sulfitobacter.
OX   NCBI_TaxID=218672 {ECO:0000313|EMBL:SDG86489.1, ECO:0000313|Proteomes:UP000199399};
RN   [1] {ECO:0000313|EMBL:SDG86489.1, ECO:0000313|Proteomes:UP000199399}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16477 {ECO:0000313|EMBL:SDG86489.1,
RC   ECO:0000313|Proteomes:UP000199399};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; FNBP01000013; SDG86489.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199399; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199399};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN      292    468       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      473    566       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      602    687       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   698 AA;  75407 MW;  255BFF44E5ACF55A CRC64;
     MTDKIAYSRH DDIVVLRIEN PPVNALSQAV RQGLAEGMDR AEAEDGVRAV MIVGEGRAFI
     AGADITEFGK PPMEPHLPNL CNRIEASPLL VVASMHGVSL GGGLEVALSA HYRIAQPSAR
     VGLPEVHLGL IPGAGGTQRL PRLIGVEPAL DAITTGRHIK APQALEMGIV DRVEEGDPQE
     VGLAYVRELL DSGAERRPIC DMPAPAPIDW DAAYEATLKK GRGQISPAEA VRAVQAGVEK
     PFEEGMKAER RIFSELMNTD QRQGMIHAFF SERAVSNLPE LKGVEPRDLK AIGVIGGGTM
     GAGIATAALL SGFSVVLIEM KDEAAKAAHE RISGNLQGAL KRGKIDQAKF DKLTGTALAV
     STKYDSLSDV DLVVEAVFED MDVKKQVFGK LDAVCKPGCV LASNTSYLDV DEIAASTSRP
     GDVIGLHFFS PAHVMKLLEV VVADKTAPEV VATGFALGKA LGKISVRAGV CDGFIGNRIL
     ATYRTAADHM VLDGASPYKI DAALEKFGFA MGPFAVADLA GLDIGWATRK RKAATRHPEE
     RVPTYIDRLC EQGHFGQKTG QGYYIYEKGK RGGTPNPEIT RLIEEEQKER GITPREFTEA
     EIVRRYMCAM VNEAAKVLEE GIAKRPLDID MTLLFGYGFP RYWGGPMKWA DIQGLPNVLA
     AIVGFAEQDP WFWKPAPLLA ELVKTNRNFD DLNKEAAK
//
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