ID   A0A1G8BLY7_9BURK        Unreviewed;       809 AA.
AC   A0A1G8BLY7;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=SAMN05444748_10185 {ECO:0000313|EMBL:SDH34242.1};
OS   Variovorax sp. OV700.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=1882826 {ECO:0000313|EMBL:SDH34242.1, ECO:0000313|Proteomes:UP000199505};
RN   [1] {ECO:0000313|Proteomes:UP000199505}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OV700 {ECO:0000313|Proteomes:UP000199505};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; FNDR01000001; SDH34242.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G8BLY7; -.
DR   STRING; 1882826.SAMN05444748_10185; -.
DR   Proteomes; UP000199505; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR   PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00989; PAS; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        257..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          291..363
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          367..419
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          570..795
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   809 AA;  89920 MW;  5E848B2CDDB1D878 CRC64;
     MLAPIAAVLL FLAAIVSSFW YLRTEEVERE QESVRRDVEY AQQRMRLRLL ERQEQLMRIA
     RDASNREIDP VEFASRAESL VSQFPELQTV AWIDDRRRFK AGYSAPSVHP SQQHLIGDVL
     RPGDIESNYA LARELRQPVF SQPMAGGDPT AMLQLHIPLF DQGLFAGVVL GEFSVDGLLR
     YGMPSEVQAR YAVSLLDAKG NVIAGNTTAS TREGGTRLLP WSERTNEYEV PVSPVGNALV
     LRAQAYRTSQ GVVGNGLFWL VCALSVLTSW MLIGTWRHTR RRQQAQQRLV AETNFRRAME
     NSMLTGMRVL DLQGRITYVN AAFCAMTGWS EAELVGQSPP FPYWLESDRE VMNERLEEEL
     HGRALPGGFQ VRVKRKNGSV FNARLYVSPL IDARGHQTGW MTSMTDITEP TRIREQLSAS
     YERFTTVLEA LDAAVSVAPI GSEELLFANK LYRLWFGSDT VGHLGMVAQA GVPTSNAHDE
     GLDDVDPYAG LPIDTLTAAQ AANNEIFVPH LGKWLEVRSR YLTWVDGRLA QLVIATDITP
     RRDAEEQAAA QADRAQAASR LITMGEMASS VAHELNQPLT AITNYCNGMM SRIKGQAIDS
     DALLAALEKT SKQAQRAGQI IQRIRSFVKR SEPNRTAADV ATMVSEAVEL AGIELRRRNV
     RLNHYVAARL PVVQVDPILI EQVMVNLLKN AAEAIDIAER PLARRSVELR VLPKVIEGHN
     AIEFSVQDTG KGLAPEVMDR LYEAFFSTKP EGMGIGLNLC RTIVESHRGR MQAENIYNGP
     DVIGCRFSFW IPVLDAPSSV ASDEAKVPA
//