ID A0A1G8BVW1_9VIBR Unreviewed; 858 AA.
AC A0A1G8BVW1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SAMN04488136_11476 {ECO:0000313|EMBL:SDH37342.1};
OS Vibrio xiamenensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=861298 {ECO:0000313|EMBL:SDH37342.1, ECO:0000313|Proteomes:UP000198854};
RN [1] {ECO:0000313|EMBL:SDH37342.1, ECO:0000313|Proteomes:UP000198854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.10228 {ECO:0000313|EMBL:SDH37342.1,
RC ECO:0000313|Proteomes:UP000198854};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FNDD01000014; SDH37342.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8BVW1; -.
DR STRING; 861298.SAMN04488136_11476; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000198854; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000198854}.
FT DOMAIN 687..703
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 505..564
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 858 AA; 95426 MW; 0325275253CA63EB CRC64;
MKADQKHTPM MQQYLALKAE NPDILLFYRM GDFYELFYDD AKRASHLLDI SLTKRGSSAG
QPIPMAGVPY HAVEGYLAKL VQLGESVAIC EQIGDPATSK GPVERKVVRI VTPGTVTDEA
LLSERVDNLI AAIYHHQGKF GYATLDVTSG RFQLCEPQTE EAMLAELQRT SPRELLFPED
FEPVQVMENR KGNRRRPVWE FELDTAKQQL NQQFGTKDLV GFGVEQAEYG LCAAGCLIQY
VKDTQRTALP HIRSLTFDRQ DSSVILDAAT RRNLEITQNL AGGSENTLAE VLDHTATPMG
SRMLKRWLHQ PMRNSEALNQ RLDAIGDIKR SALFTELNPV LKQIGDIERI LARLALRSAR
PRDMARLRNA MQQLPELAQV LTEVSHPYLQ KLTEYCAPQE EICQLLERAI KENPPVVIRD
GGVIASGYNA ELDEWRNLAD GATEYLEALE REERERHGID TLKVGYNNVH GFYIQVSRGQ
SHLVPPHYVR RQTLKNAERY IIPELKEHED KVLNSKSKAL ALEKQLWEQL FDLLMPSLEA
LQNLASALSQ LDVLQNLAER AESLDYCRPE LTDHVGIHIQ GGRHPVVEQV MDEPFIANPI
ELSPERKMLI ITGPNMGGKS TYMRQTALIA LMAHIGAYVP AESAHIGSID RIFTRIGASD
DLASGRSTFM VEMTETANIL HNATERSLVL MDEIGRGTST YDGLSLAWAS AEWLAKQIGA
LTLFATHYFE LTELPKQIAT LANVHLDAVE HGDSIAFMHA VQEGAASKSY GLAVAGLAGV
PKSVIKNART KLTQLEQLSK AESLTTGATS SGNGVDIANQ LSLIPEPSEV EEALATIDPD
DLTPRQALDA LYRLKKLL
//
