ID A0A1G8BX11_9MICC Unreviewed; 1104 AA.
AC A0A1G8BX11;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN04488693_10180 {ECO:0000313|EMBL:SDH37629.1};
OS Arthrobacter subterraneus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=335973 {ECO:0000313|EMBL:SDH37629.1, ECO:0000313|Proteomes:UP000199258};
RN [1] {ECO:0000313|EMBL:SDH37629.1, ECO:0000313|Proteomes:UP000199258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NP_1H {ECO:0000313|EMBL:SDH37629.1,
RC ECO:0000313|Proteomes:UP000199258};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNDT01000001; SDH37629.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8BX11; -.
DR SMR; A0A1G8BX11; -.
DR STRING; 335973.SAMN04488693_10180; -.
DR OrthoDB; 5240387at2; -.
DR Proteomes; UP000199258; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199258}.
FT DOMAIN 31..332
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 358..656
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 351..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 52..59
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1104 AA; 118172 MW; B47E2BD368C83645 CRC64;
MNRSPAVAPA SPYAGLRLSS GMAEGPQRPV LSAEQAEIVS LGAGSGPVLV LGGPGSGKTQ
VLVELAVRRI LNGDTGPDRM LIVAPTRLAA ARLRDSITAR LERSLSAPPA RTWSSYAFDL
IRRARVAGLL PELARSPRLL SGAEQDLIIR ELLDGHRRLG LLESRWPDGL RLALGTRGFR
QEVRELFDRV SEYSLHADDL TDLGLRFDRP DWVAAAALYS EYRDVLDLRM PEAFDPAGIL
TAARGILETD PGFCAEERSR YELILIDDYQ ESNTAMHALC GVLAEGKDAF ITACPDTAVQ
GFRGARPDLA GRLPEELGQV RMAQLTGSHR LTGRLATGWV SVAARTPVSG TPVGYRRLAE
PGGGSGQGEL SGGSSQGECG PSRPAGAELS VHVVDSGYHE QRYVAQRILE AHVEQGRSFS
DIAVITRTGA QVAELQRYLA GQDIPVSVPP AERAIRDEPA VRPLLDILAV VTGVRELDAE
LAVSIMTSRV GGAGPLEIRR LRQLLRQEER LAGGVRDSDQ LIVDLFSGKT VDDYRPQLRP
VRRLSLMLNA GREAIEDDAS TPETVLWAVW SASGLSPRWE EAALRQGPPS ARADRDLDAV
VALFQTAERY VDQMPGAPAA GFLEYLLSQE LPMDTLAARA QKGAAVEILT PAAAAGREWP
VVLVAGVQEG TWPNLRIRGE LLGSGDLVAL LEHGSQFRHH RDPLSLMQLT RADELRTFSA
AVSRASEELV CIAVSSEDQQ PSSFLDILDP LPPGRYERPR TEVKRPLTLR ALVAELRRYA
QQPGRNAGAA AEAVRHLGTM VLHEPRVPGA DPDQWWGLAG LSSTGPVVPP EAAIPVSPSK
VEAVLASPLN WFVSAAGGER PTDFARSLGT LVHSIAQDIP DGTGNQYVAE LVRRWPSLGM
KDTWESKADL RRAGEMVRKL GGYLVEMRKA GRVLASTEVS FSVDLPVMTD GGARTARLRG
QVDRVEITHD GCLFIVDLKT GRNAPRDADV PAHPQLAAYQ VAATAGGLSE VDGDSAGGSP
AAPGSGGAAL VQLGTSAKSP KVQNQPPLGP EESWAHEMIG QAASLMAAAA FEAVHDPGRS
SHGGGGCRLP EICPLCVEGR QVTE
//
