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Database: UniProt
Entry: A0A1G8DL19_9PSED
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ID   A0A1G8DL19_9PSED        Unreviewed;       714 AA.
AC   A0A1G8DL19;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   08-MAY-2019, entry version 10.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase {ECO:0000313|EMBL:SDH58357.1};
GN   ORFNames=SAMN05216603_110176 {ECO:0000313|EMBL:SDH58357.1};
OS   Pseudomonas benzenivorans.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=556533 {ECO:0000313|EMBL:SDH58357.1, ECO:0000313|Proteomes:UP000199168};
RN   [1] {ECO:0000313|EMBL:SDH58357.1, ECO:0000313|Proteomes:UP000199168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 8628 {ECO:0000313|EMBL:SDH58357.1,
RC   ECO:0000313|Proteomes:UP000199168};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01133165};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-hydroxyacyl-CoA = a (3E)-enoyl-CoA +
CC         H2O; Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|SAAS:SAAS01123900};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FNCT01000010; SDH58357.1; -; Genomic_DNA.
DR   BioCyc; GCF_900100495:BLS63_RS17605-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199168; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199168};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   Lyase {ECO:0000256|SAAS:SAAS00999128};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00999134};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN      318    496       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      499    599       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   714 AA;  76810 MW;  BCFCA7F3BFF2318D CRC64;
     MTDAIRYEKG QDAIVVLTID MPGQSANTMN AQYREAMGQV VERLEAEKDS IAGVIVTSAK
     KTFFAGGDLN ELIKVSKADA DAFYRMILKI KGQLRRLECL GKPVVAAING AALGGGWEIC
     LACHHRIALD SSSVQLGLPE VTLGLLPGGG GVVRMVRLLG LEKALPYLAE GKKVRPEAAL
     KAGLIDELAS DKDDLLAKAR AWIAANPAPR QPWDLPGYKI PGGTPSSPNV AQMLAIAPSV
     LRDKTKGCFP APEKILCAAV EGAQVDFDTA QLIEARYFTE LTTGQVAKNM IGTFWFQLNE
     INAGGSRPQG FAPYLTKKVG VLGAGMMGAG IAYVSALAGI EVVLKDISLE AAEKGKSYSA
     KLLEKKVGRG QMSAEKRDAI LARIATTDKD ADFAGCDLII EAVFEDRDLK ANVTAAAERA
     ALAEAVIASN TSTLPITGLA NAVQKQDRFI GLHFFSPVDK MPLVEIIRGE RTSDETLARG
     FDYVMQIKKT PIVVNDSRGF FTSRVFGTFT NEGIAMLGEG VSAALIENEA RKAGMPVGPL
     AISDEVSLSL MQHIRQQTLK DLAEEGKSLP EHPAFAVIES MLGEYKRPGK AAGGGFYEYP
     AGGKKYLWPE LKSRFEKADR QIPQEDVRDR ILFIQAIETV RCVEEGVLNS TADANIGSIF
     GIGFAAWTGG ALQFINQYGI QDFVARAQYL AEQYGERFLP PALLLEKAAK GESF
//
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