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Database: UniProt
Entry: A0A1G8DP42_9FLAO
LinkDB: A0A1G8DP42_9FLAO
Original site: A0A1G8DP42_9FLAO 
ID   A0A1G8DP42_9FLAO        Unreviewed;       443 AA.
AC   A0A1G8DP42;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE            Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
DE            EC=1.1.1.88 {ECO:0000256|RuleBase:RU361219};
GN   ORFNames=SAMN05421846_101256 {ECO:0000313|EMBL:SDH59493.1};
OS   Chryseobacterium taeanense.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC   Chryseobacterium group; Chryseobacterium.
OX   NCBI_TaxID=311334 {ECO:0000313|EMBL:SDH59493.1, ECO:0000313|Proteomes:UP000198869};
RN   [1] {ECO:0000313|Proteomes:UP000198869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17071 {ECO:0000313|Proteomes:UP000198869};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-
CC         methylglutaryl-CoA + 2 H(+) + 2 NADH; Xref=Rhea:RHEA:14833,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.88;
CC         Evidence={ECO:0000256|RuleBase:RU361219};
CC   -!- PATHWAY: Metabolic intermediate metabolism; (R)-mevalonate degradation;
CC       (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361219}.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
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DR   EMBL; FNDW01000001; SDH59493.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G8DP42; -.
DR   STRING; 311334.SAMN05421846_101256; -.
DR   OrthoDB; 9764892at2; -.
DR   UniPathway; UPA00257; UER00367.
DR   Proteomes; UP000198869; Unassembled WGS sequence.
DR   GO; GO:0140643; F:hydroxymethylglutaryl-CoA reductase (NADH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR   Gene3D; 1.10.8.660; -; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR   PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR   SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|RuleBase:RU361219};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU361219}.
SQ   SEQUENCE   443 AA;  49776 MW;  589FEBBC7D520A72 CRC64;
     MNHKPVEGFS KLTKQGKIDW LVNEYLEGNE EYQNILNQYW NDNADLQKLH DEFSENTISN
     FYMPYGIAPN FLIDGKLFAL PMAVEESSVV AAASKAAKFW LDKGGFKTTI INNEKLGHTH
     FIFNVESHKL LHFFNFSLKK KLLESTEDIT ANMRKRGGGI LDIKLIDKTS EMPNYYQLKA
     SFDTVDSMGA NFINSCLEQF GKTLKQEVAI SEDFSQEEKN SLQIVMNILS NFTPDCIVRA
     EVSCKIEDLK DDSGISNEEF AWKFKQAVTI AEIEPFRATT HNKGIMNGVD AVVIATGNDF
     RATEACAHAY AARNGKYSSL THCTIDNGIF RFWIDLPISV GVVGGLTNLH PLVKFSLALL
     GKPSAQELMS VLAVSGLAQN FGALRSLVTT GIQKGHMKMH LLNILNQMGA TEEEKEHFVT
     YFKDKTVSHH EVIYEFNRLR GNN
//
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