ID A0A1G8DPE5_9PSEU Unreviewed; 395 AA.
AC A0A1G8DPE5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DNA helicase-2 / ATP-dependent DNA helicase PcrA {ECO:0000313|EMBL:SDH59593.1};
GN ORFNames=SAMN05216553_1337 {ECO:0000313|EMBL:SDH59593.1};
OS Lentzea fradiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=200378 {ECO:0000313|EMBL:SDH59593.1, ECO:0000313|Proteomes:UP000199623};
RN [1] {ECO:0000313|Proteomes:UP000199623}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.3506 {ECO:0000313|Proteomes:UP000199623};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNCC01000033; SDH59593.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8DPE5; -.
DR STRING; 200378.SAMN05216553_1337; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000199623; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 10..286
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT REGION 366..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..395
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 31..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 395 AA; 43420 MW; 3D52878C4882574F CRC64;
MSRLSESIDD LKQNERQWEA FTTEGHCVVL APPGSGKTKL LATRMAHDLA TKIRRPQGAA
CITLTNAAAD QLRRRVGLLG VEDRPSLFIG TVHSFLLGKV LAPFAYAIGR PELASITIVS
EEEGDKLLSQ AVAEAIPWGD TTNVASTISF NRRRLASVEE WAKSGEGVRE AARLYEAKLQ
ERGLHDFDGV VATAVELVED HLLVRQVLTA QYPHLYVDEY QDLSPGLDRV VKALCFDYFN
GAELFAVGDP DQALFGFTGT RPELLTELAD RPDVTSVELT RNYRSRDEIL KVANRMRDGR
SPMVGHQPGG RVSVLKCPEG RPGQYARVAA AVRQANADGV PLHEIAVLCP TGPMCQEAVS
SLRQNGIPAF YRNKKPSTTR TRSPRSSKPP RRGRL
//