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Database: UniProt
Entry: A0A1G8DV87_9BACI
LinkDB: A0A1G8DV87_9BACI
Original site: A0A1G8DV87_9BACI 
ID   A0A1G8DV87_9BACI        Unreviewed;       796 AA.
AC   A0A1G8DV87;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   05-JUN-2019, entry version 10.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SDH61370.1};
GN   ORFNames=SAMN05192534_10833 {ECO:0000313|EMBL:SDH61370.1};
OS   Alteribacillus persepolensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae;
OC   Alteribacillus.
OX   NCBI_TaxID=568899 {ECO:0000313|EMBL:SDH61370.1, ECO:0000313|Proteomes:UP000199163};
RN   [1] {ECO:0000313|EMBL:SDH61370.1, ECO:0000313|Proteomes:UP000199163}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21632 {ECO:0000313|EMBL:SDH61370.1,
RC   ECO:0000313|Proteomes:UP000199163};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; FNDK01000008; SDH61370.1; -; Genomic_DNA.
DR   BioCyc; GCF_900099605:BLT18_RS08110-MONOMER; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000199163; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000199163};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199163}.
FT   DOMAIN        7    205       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      208    306       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      368    420       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   REGION       43     78       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1G8DV87}.
FT   COMPBIAS     43     70       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A1G8DV87}.
SQ   SEQUENCE   796 AA;  88056 MW;  5DBA49B76AA66F8A CRC64;
     MTATIQKAAV LGSGVMGSSI AAHLANVGIS VLLLDVVPKE TNDKEKAKGL TTSDRSVRNR
     FSEQAKQKLR KQKPAPLTSK SKLSLIEAGN MEDDMQRLSE ADWIIEAVIE DLGVKQHVLK
     VVEGYRKPGS IVSSNTSGIA INEMADGLSE EFRSHFLGTH FFNPPRYLKL LELIPNRYTD
     PAVKTEMKDF AENTLGKGVV EAKDTPNFIA NRIGTYGFLI TVHEMLRQGW SVSEVDSITG
     AVIGRPKSAT FRTLDVVGLD TFLHVAKNVY DKVDGQEKSV FQPPAFMKEM EERGWLGSKS
     GQGFYKKVTG ENGKEILELD VDTFTYQPRK RIKAKSLEEA GRKTSTREKL KTLVYADDQA
     GRFIWNILKP LLLYTAEKAE EIANNIAAVD QAMKWGFGFE LGPFETWDAI GVEQSAARME
     EEGETLPVWV KEMLHQGYKS FYSSAQEYYH KGKYLKINSN TKNIDLGKRK AVQGAVIHRN
     AGASFIDIGD GVACLELHSP NDSIGLDAIH MINTAVYETE KNYKGLVIAS RSKNFCVGAN
     IMMMLMEAQD DNFVEIDMVV RKFQQAMQKI KYAKRPVVAA PYGMTLGGGT ELCLPAASIQ
     AASETYMGLV ETGVGLIPAG GGTKELYRRH IESFPQHGKK ELLAAANQVF EKIALASVST
     SAEEAKDNKF LSSTDNIIFN QDHLLYYARQ KVLHLYETGY KPPLRQKIPV TGKTGYAAMK
     LGAKTFHFGG RASAHDVKIA EKLAFVIAGG NVACGTLVDE DYLLDLEREA FLNLMGEPKS
     QARMQYMLMK GKALRN
//
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