ID   A0A1G8F4B0_9ACTN        Unreviewed;       565 AA.
AC   A0A1G8F4B0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Protease-4 {ECO:0000313|EMBL:SDH76983.1};
GN   ORFNames=SAMN05421505_12247 {ECO:0000313|EMBL:SDH76983.1};
OS   Sinosporangium album.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Sinosporangium.
OX   NCBI_TaxID=504805 {ECO:0000313|EMBL:SDH76983.1, ECO:0000313|Proteomes:UP000198923};
RN   [1] {ECO:0000313|EMBL:SDH76983.1, ECO:0000313|Proteomes:UP000198923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CPCC 201354 {ECO:0000313|EMBL:SDH76983.1,
RC   ECO:0000313|Proteomes:UP000198923};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S49 family.
CC       {ECO:0000256|ARBA:ARBA00008683}.
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DR   EMBL; FNCN01000022; SDH76983.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G8F4B0; -.
DR   STRING; 504805.SAMN05421505_12247; -.
DR   OrthoDB; 9764363at2; -.
DR   Proteomes; UP000198923; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   CDD; cd07018; S49_SppA_67K_type; 1.
DR   CDD; cd07023; S49_Sppa_N_C; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR004634; Pept_S49_pIV.
DR   InterPro; IPR002142; Peptidase_S49.
DR   InterPro; IPR047217; S49_SppA_67K_type_N.
DR   InterPro; IPR047272; S49_SppA_C.
DR   PANTHER; PTHR33209; PROTEASE 4; 1.
DR   PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR   Pfam; PF01343; Peptidase_S49; 2.
DR   PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SDH76983.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198923};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          97..248
FT                   /note="Peptidase S49"
FT                   /evidence="ECO:0000259|Pfam:PF01343"
FT   DOMAIN          349..499
FT                   /note="Peptidase S49"
FT                   /evidence="ECO:0000259|Pfam:PF01343"
FT   ACT_SITE        167
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT   ACT_SITE        365
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ   SEQUENCE   565 AA;  60613 MW;  0CF17E69689B7479 CRC64;
     MDPTKAIIDT VERFKQRRTA PLVLELDITE GFIEGPPSDP VEALLTMRKA RLADVLSGLK
     RARQDPRVKA LIVKIGGPLG LAAVQELRQA VIRLRAAGKL TVAYAETFGE FGAGTVPYYL
     ATAFERVYLQ PSGDIGLTGV VIEQHFVKSA LDKLGVDYQL GQRHEYKTAA NTFTQDHMTD
     AHRESSARIV RSITEQAVAG IAEGRGLSPE RVRELIDQGP FIGAEALSAG LVDGLAYRDE
     VYAEVKRSVG DDAHLLYVGR YNKTIKNFKM PHPGAQSVAL IHGHGAIRLG RSGRSPLGGG
     GAMGADTICA AFRAARRDDS VKAVVFRVDS PGGSYVASDA IWREVVLTRE AGKPVIVSMG
     QYAASGGYFV SMAANVIVAQ PGTLTGSIGV YGGKMVTDEL LGKLGIASDR VAEGANAGMF
     LGSRPFSTDE WGRVNAWLDR IYQDFVSKAA DGRKFTFDEA HELAKGRVWT GADARENGLV
     DELGGLEDAV SLARDRAGLA DDAPVRVYPK AGPLERLRPA ESSEDRSAAL ARMRVSAWGP
     LARFAAELGL PSHGPLILPG AWRIR
//