ID A0A1G8F592_9NOCA Unreviewed; 1078 AA.
AC A0A1G8F592;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN05444695_103173 {ECO:0000313|EMBL:SDH77169.1};
OS Rhodococcus triatomae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=300028 {ECO:0000313|EMBL:SDH77169.1, ECO:0000313|Proteomes:UP000183263};
RN [1] {ECO:0000313|EMBL:SDH77169.1, ECO:0000313|Proteomes:UP000183263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44892 {ECO:0000313|EMBL:SDH77169.1,
RC ECO:0000313|Proteomes:UP000183263};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; FNDN01000003; SDH77169.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8F592; -.
DR Proteomes; UP000183263; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000183263}.
FT DOMAIN 24..335
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 336..636
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 45..52
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1078 AA; 115000 MW; 7052861C0ED34B3D CRC64;
MRLVRRQTRV QEPREWDPAA LRVLEDTGAG GPRLGGGWRP WQVLGGPGTG KTALVVDSAV
RRILAGADPE SVLVLVHSRR AAVAVREQIT AALTAGGAGR PRASREPLVR TVHSYAFAVL
RLQAAAHGNP PPRLITGAEQ DSAIREMLRG EIEDGAAEWP DRLRPALATL GFAAELRDLI
MRAAERGLGP EDLSDLGRAE GREEWVAAGR FAARYEQATL LRATVGMHAP EATAPALDAA
ELVSAALEAF ATDPELLRRE RARVRHLLVD DAQHLDPQAA QLIRLVGTGA DSAVVAGDPD
QSVFAFRGAD PSFLTGLAER HDERQVLLPR NHRAAAEIAD ATRRILGRLP GSGPQRAWEA
GTSEGRVAIR VASSPAKEAA VVADTLRRAH LTDGIAWSRM AVVVRSVPAS LAPLRRALLA
AGVPVTTPAD ELPLARRHGV SALLLVLRAV TEREFTGDDA LALLSGPIGG AEPVALRRLR
RGLRRSELSG GGDRDSSEIL RRIVLGADEP AMRGLTEVEA APLQRVGKVL RRARKVLGDG
GGVEDVLWAA WRAAGLEKRW AAASLRGGPV GAQADRDLDA VVALFDAAAG YVDRLPRAGI
AGFLDHVEGQ EIPTLSRTTP LFTESVTVLS AHAAVGREWD VVAVVGVQEG TWPSLRSRSS
LLGTGELIDL VSGTVRSAGD TRLSRTAPLL AEERRLFLLA CSRARRILSV TAVDAPGGDA
DLVRSRFVDE LAVDGDTPDA LPEPVTEPPA RVLALPALVA ELRAVVCDSA ADQGRRDRAA
VQLARLAEAG VRGAHPDQWY GLADPSTAEP LWGPEDGPVP LSPSTIEQLT TCPLRWLLER
NGGTDGDNAR AVAGTLVHTL VQALAGHIPP DHVDRALEEA WAAVDLGSPW YSRRELTRTR
TMLETFAAWM RASRSELTEI GVEVAVDGVL EPRSDGDPQV RLRGRIDRLE RDAEGRPVVV
DVKTARTPVS RSQAEEHAQL AAYQVAAATG AVEGMPPARP GGARLVFVAK PHKKDGATER
VQAPLSDADL ERWIDAVHAA AAATRGPRFL AQVNDGCRHC PVRSSCPVHD EGRQVSAQ
//
