ID A0A1G8GWD8_9RHOB Unreviewed; 696 AA.
AC A0A1G8GWD8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|ARBA:ARBA00017846, ECO:0000256|RuleBase:RU363016};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU363016};
GN Name=recG {ECO:0000256|RuleBase:RU363016};
GN ORFNames=SAMN05421850_101251 {ECO:0000313|EMBL:SDH98659.1};
OS Lutimaribacter saemankumensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Lutimaribacter.
OX NCBI_TaxID=490829 {ECO:0000313|EMBL:SDH98659.1, ECO:0000313|Proteomes:UP000199340};
RN [1] {ECO:0000313|EMBL:SDH98659.1, ECO:0000313|Proteomes:UP000199340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28010 {ECO:0000313|EMBL:SDH98659.1,
RC ECO:0000313|Proteomes:UP000199340};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC Holliday junction intermediates to mature products by catalyzing branch
CC migration. Has a DNA unwinding activity characteristic of a DNA
CC helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC DNA). {ECO:0000256|RuleBase:RU363016}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363016};
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504, ECO:0000256|RuleBase:RU363016}.
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DR EMBL; FNEB01000001; SDH98659.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8GWD8; -.
DR STRING; 490829.SAMN05421850_101251; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000199340; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd17992; DEXHc_RecG; 1.
DR CDD; cd04488; RecG_wedge_OBF; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR InterPro; IPR033454; RecG_wedge.
DR NCBIfam; TIGR00643; recG; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF17191; RecG_wedge; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363016};
KW DNA damage {ECO:0000256|RuleBase:RU363016};
KW DNA recombination {ECO:0000256|RuleBase:RU363016};
KW DNA repair {ECO:0000256|RuleBase:RU363016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363016};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363016};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363016};
KW Reference proteome {ECO:0000313|Proteomes:UP000199340}.
FT DOMAIN 282..443
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 466..627
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 696 AA; 75694 MW; 1221E8CDE0D7D868 CRC64;
MSGRPEQLFP LFAGIDTLPG VGPKTAGLLE HLEITRPRDL ILTLPHTGID RRRRDSVLGA
DLPQVLTVEV MVGQHRAPAR KGGAYRVTVE DAKTSFQLVF FHARGDYLQK LLPTGQRRVV
SGRVELFDGI AQMVHPDHVV TVDEAADIPA FEPVYPLTHG VSLKQMTKAV QGALSRVPDL
PEWIDPEQKR QAGWPDWHAA IAAAHAPQTL ADLAATAPAR ERLAYDELMA HQLTLALARS
KLRRAKGRQT KGTGALQARV LTALPYAPTG AQTRAVGEIA DDMANPLRMN RLLQGDVGAG
KTLVAFMALL IAVEAGGQGV MMAPTEILAR QHLEGLRPMA EDAGVVLEIL TGRDKGAERK
AKLAALARGD IHVLVGTHAV FQKDVEFHDL RLAVVDEQHR FGVRQRLELG RKGQAVDVLV
MTATPIPRSL ALAQYGDMDV SVLDKKPPGR KPIKTALISN GRMDEVVDHL RKAVAEGRQA
YWVCPLVDES ELVDLTAAED RFKRLRAALG EGVVGLVHGQ MPPAEKDAAM AAFQRGETSV
LVATTVIEVG VNVPNATIMV IERAEIFGLA QLHQLRGRVG RGDQASTCLL MYQPPLSEGG
ERRLTTLRDT EDGFRIAEVD LDMRGAGDLI GTAQSGLPRF RVADLERQAA LMATAQSDAR
KLMADDPELQ SDRGRAARIL LWLMEQDQAI RLISVG
//
