ID A0A1G8H1S0_9RHOB Unreviewed; 808 AA.
AC A0A1G8H1S0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=SAMN05421850_101322 {ECO:0000313|EMBL:SDI00583.1};
OS Lutimaribacter saemankumensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Lutimaribacter.
OX NCBI_TaxID=490829 {ECO:0000313|EMBL:SDI00583.1, ECO:0000313|Proteomes:UP000199340};
RN [1] {ECO:0000313|EMBL:SDI00583.1, ECO:0000313|Proteomes:UP000199340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28010 {ECO:0000313|EMBL:SDI00583.1,
RC ECO:0000313|Proteomes:UP000199340};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; FNEB01000001; SDI00583.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8H1S0; -.
DR STRING; 490829.SAMN05421850_101322; -.
DR Proteomes; UP000199340; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000199340};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 568..763
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 199..226
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 658
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 808 AA; 88194 MW; A98A47CBE2429052 CRC64;
MTALPPEKLR PRCDPSSLPF RTTDELPDHS DLIGQDRALE AIRLSAEVTH RDFNLFVLGP
SGTGRHAAIE EVLKAQSGQR PLPVDWVYVN NFDAPHKPRA LSLPPGHAPR LRAAMQDLVN
DLARDLPAVF ESDEYQTQRR AIDQEYAEKQ EGAMSDFADA ARAEGVALLR TPMGFMLTAL
KDGEVLKTED FGKLPEKEQD EIEEKIARLQ EDLADVLRQA PRLERAHAKR IEQLNAETAA
RTVSSRIEEF DPTLRAIKAV SDYVLEVEQD IIAHADLFLQ AVAQGGDGGF PGPLRKFHED
PAFDRYVVNV MVSHSGKDGK GAPVETEHTP TLDRLVGRIE HVSQMGSLVT NFTMIKPGAL
HRANGGFLML EARALLSEPF AWDALKQCLK TRSINITSLA ERLSMMSTTS LEPDPIPLDL
RIVLIGDRML HALLVMLDPD FGDLFKIQAD FEESVPRGDR ETDALYARLI GAYSRREGLP
AITAAGVARI IDEAARRAED NTRLSLRLGQ IGDLVKEAAH YAKARGAARI EAEDIDHACE
AQDRRAGRIK DRMQEAIGRG TVLIDTQGAQ IGQINGLSVI GLGNYSFGRP SRITARVRMG
AGKLVDIERE VELGGPLHSK GVMILSGYLT SRYALDVPFS LHASLVFEQS YGGIDGDSAS
SAELYALLSA LSEAPLEQGL AVTGSVNQAG EVQAIGGVNE KIEGFFETCR ARGLTGTQGV
LIPKANVEHL MLNDDVVAAA REGKFRVIPV STIDEGISLL TGIDAGTRDG TGKFPKGSIN
ARVEARLRGF AETRRDFLRR KTDGGDAE
//
