ID A0A1G8IYR8_9NOCA Unreviewed; 538 AA.
AC A0A1G8IYR8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SAMN05444695_1066 {ECO:0000313|EMBL:SDI23996.1};
OS Rhodococcus triatomae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=300028 {ECO:0000313|EMBL:SDI23996.1, ECO:0000313|Proteomes:UP000183263};
RN [1] {ECO:0000313|EMBL:SDI23996.1, ECO:0000313|Proteomes:UP000183263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44892 {ECO:0000313|EMBL:SDI23996.1,
RC ECO:0000313|Proteomes:UP000183263};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FNDN01000006; SDI23996.1; -; Genomic_DNA.
DR RefSeq; WP_072740358.1; NZ_FNDN01000006.1.
DR AlphaFoldDB; A0A1G8IYR8; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000183263; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000183263}.
FT DOMAIN 18..163
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 177..499
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 538 AA; 59035 MW; 4B1CD015251F5913 CRC64;
MPPRKKSASS APSTMKELKD TLWKAADKLR GSMDASQYKD IILGLVFLKY VSDAFEERRA
QIHDEMVAEG LDEDAIVELV DVPDEYVGGS VFWVPAPSRW SYLAENAKGI QESSSADAKT
IGQVVDDAMR ELVAANPTLE GITQTSFNSP AVDQRRLGEL IDLLGDTRFT GHGATKARDL
MGEVYEYFLE KFARAEGKRG GEFYTPPGVV RVLVEVLEPY GGRVYDPCCG SGGMFVQTEK
FIERHGGSPT EAAVYGQESN QRTWQMAKMN LAIHGITANL GGKWDDTFAH DRHPDLLADY
VLANPPFNIK DWARREDDKR WRFGVPPSGN ANYAWIQHIV SKLAERGSAG IVMANGSMSS
NSGGEGEIRA QLVEADLVSC VVALPTQLFR STGIPVCVWF LARDKSAGPK GSVDRQGQVL
FIDARNLGYM VDRAERALSG EDIAKIAGAF HAWRGTESAG DAVYKDEPGF CYSASLAEIK
EAGYALTPGR YVGAPQLEDD GEPIGEKIER LTKELFAQFE ESDRLQAVVR EQLGRVLS
//
