ID A0A1G8JWN4_9BACI Unreviewed; 803 AA.
AC A0A1G8JWN4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Multisubunit sodium/proton antiporter, MrpA subunit {ECO:0000313|EMBL:SDI34990.1};
GN ORFNames=SAMN04488123_101407 {ECO:0000313|EMBL:SDI34990.1};
OS Natribacillus halophilus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Natribacillus.
OX NCBI_TaxID=549003 {ECO:0000313|EMBL:SDI34990.1, ECO:0000313|Proteomes:UP000198853};
RN [1] {ECO:0000313|EMBL:SDI34990.1, ECO:0000313|Proteomes:UP000198853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21771 {ECO:0000313|EMBL:SDI34990.1,
RC ECO:0000313|Proteomes:UP000198853};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A
CC family. {ECO:0000256|ARBA:ARBA00008483}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNEN01000001; SDI34990.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8JWN4; -.
DR OrthoDB; 9807568at2; -.
DR Proteomes; UP000198853; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR005663; MrpA/MnhA1/PhaAB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR NCBIfam; TIGR00940; 2a6301s01; 1.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198853};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 776..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..112
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 129..421
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 637..700
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 718..794
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
SQ SEQUENCE 803 AA; 88511 MW; 00A00B913824D4C6 CRC64;
MSFLHWAILI PFLFAIIVPM LYKYIRPVHT GWFILIVPSV LFVFFLPYIN PVADGETFME
TVPWVPSLGI NFSAFIDGWS LLFALLITGI GALVVLYSIY YLDKKYEDLT NFYVHLLMFM
GAMLGVVLSD NVIVLYVFWE LTSISSTLLI SYWYHRDASI NGALKSLNIT VLGGFAMLAG
FALLYVMTGT FSIQEMIGQA GGVIDHPLFL PTIILILLGA FTKSAQFPFH IWLPDAMEAP
TPVSAYLHSA TMVKAGIYLV ARFTPLFGGA PEWFWIIAGG GLLTLLWGSL SAIRQKDLKG
LLAYSTVSQL GMVMCLLGLG SAALYFDDAN ELYTVAILAA VFHLFNHASF KGSLFMTAGI
VDHETGTRDI RALGGLMLVM PATATISLIG AASMAGIPPL NGFLSKEHFF MAITDATEYG
IFNMETAGML FPVIGWLASV FTFVYCCIFF FKTFAGPFEP ERFAKKVHEA PIGMLISPAV
LGLVVVIVGI FPNLLSQSII EPSMAAILQG LPTDAEAFTV DIEHWHGFDL ELFMTIGVVG
FGSLLYLAMG KWRKLSIYNK TTDPFSPVYD SGITGLLKGS RLITNVQMTG RLRDYLTFVS
AFFLIITIWT MIRYDAFVID TQNISEISTY EVVLVGLLVI SMLALPFIQQ RVAAIVVLGF
VGFLIALFFV NFRAPDLALT QLLIETVLVI LFMLAFYHLP EFRKEKMKAS FKWSNALLSF
GVGLMVTLIA LSAFSYGQGH DFSPVSDYYI ENSADLAGGY NMVNVVLVDF RALDTVLEVL
VLGVAALAVV ALIRLKMKEG DDI
//
