ID A0A1G8LJV4_9PSED Unreviewed; 785 AA.
AC A0A1G8LJV4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=SAMN05216588_11937 {ECO:0000313|EMBL:SDI56009.1};
OS Pseudomonas flavescens.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=29435 {ECO:0000313|EMBL:SDI56009.1, ECO:0000313|Proteomes:UP000198606};
RN [1] {ECO:0000313|EMBL:SDI56009.1, ECO:0000313|Proteomes:UP000198606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 18387 {ECO:0000313|EMBL:SDI56009.1,
RC ECO:0000313|Proteomes:UP000198606};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; FNDG01000019; SDI56009.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8LJV4; -.
DR STRING; 29435.SAMN05216588_11937; -.
DR Proteomes; UP000198606; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05784; DNA_polB_II_exo; 1.
DR CDD; cd05537; POLBc_Pol_II; 1.
DR Gene3D; 2.40.50.590; -; 2.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF21474; DNApolII_N; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 200..296
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 378..735
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 785 AA; 89348 MW; CD54EAB7DD64EF37 CRC64;
MDLQQGFVLT RHWRDTPAGT LVEFWLSTEG GPRLVRLPPQ TSVAFIPVAQ RARAEAVLGT
ETDIELRPLQ LRDFRQRPVL GLYCRQQRPL IQLEQTLRQA GVDVYEADVR PPERYLMERF
ITAPVLFGGT PTDEGVLVDV QLKPAPDYRP QLKLVSLDIE TTARGELYSI ALEGCGQRQV
YMLGPPNRDG EVDFDLAYLD SRAALLEALN GWLERFDPDA IIGWNVVQFD LRVLHEHAQR
LHVPLRLGRG GEVLNWREHG SKQHFFASAP GRLIIDGIEA LRSATWSFPS FSLESVAQQL
LGEGKAIDNP YQRMDEINRL FAEDKPALAR YNLKDCELVT RIFAKTELLT FLLERATVTG
LPVDRSGGSV AAFSHLYMPL MHRQGFVAPN QGERPPEASP GGFVMDSRPG LYESVLVLDY
KSLYPSLIRT FLIDPVGLVE GLRQPDDEHS IPGFRGARFS RTRHCLPAIV ERVWQGREAA
KRAGNAPLSQ ALKIIMNAFY GVLGSSGCRF FDTRLASSIT LRGHDVMRRT RELIEAEGHA
VIYGDTDSTF VWLRSAHAEE DAERIGRSLV QRVNAWWSEH LQAEFGLQSA LELQFETHFS
RFLMPTIRGM EEGSKKRYAG LIRRADGREE MVFKGLETVR SDWSPLARQF QQELYLRIFK
RQPYQDYVRD YVRGTLAGEF DERLVYRKRL RRRLDDYQRN VPPHVRAARL ADAHNDEQGR
PRQYQSGGWI SYVMSVAGPE PLELRRAPID YGHYLTRQLQ PVADAILPFV DDDFSALIGG
QLELF
//
