ID   A0A1G8N4Q4_9BURK        Unreviewed;      1085 AA.
AC   A0A1G8N4Q4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   ORFNames=SAMN05444748_10725 {ECO:0000313|EMBL:SDI75162.1};
OS   Variovorax sp. OV700.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=1882826 {ECO:0000313|EMBL:SDI75162.1, ECO:0000313|Proteomes:UP000199505};
RN   [1] {ECO:0000313|Proteomes:UP000199505}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OV700 {ECO:0000313|Proteomes:UP000199505};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; FNDR01000007; SDI75162.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G8N4Q4; -.
DR   STRING; 1882826.SAMN05444748_10725; -.
DR   OrthoDB; 5905204at2; -.
DR   Proteomes; UP000199505; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          12..483
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          520..788
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1085 AA;  119565 MW;  444825F07DB7CFDE CRC64;
     MNGAAYEHNG RHVSREAFYT VACDPRRSVA VEACAGAGKT WMLVSRILRA LLEEGESACE
     PHEILAITFT KKAAGEMRER LDQWLEQFAE RSPEELVREL VIRGVAPAAA LAAVPRLQGL
     YRRLLEGGRP VQFRTFHAWF AGLLRNAPLA VLRELGLPAN YELLEDDAEA RARTWRPFFE
     AVTSDKEALA DYYAVVATYG RSQTAKALGE ALTRRVEFVL SDPASAVQHF SAMHPALEGM
     DEPTDALSGD AARRRWLDRA AALGREANKT PQKAAEAIID VFGTGEPPHE SRSAALAHLR
     KNFFVAVEDR LTKNLQKYPA AQEAEAELQT LCAAQAQHAA WLYQQRMTRL TRILISVFAE
     VKRAHGWVDM NDVEQAAQLL LGQSALSGWV QERLDARIAH LLIDEFQDTN PLQWQALYGW
     LSAYTGAGGS APRVFIVGDP KQSIYRFRRA EPQVFIAAKK FVREGLGGEL LNCDHTHRNA
     RSVVELVNQA MLAAQEAGEF DGYRAHTTER NDDGELLKLP PIDRDALNTT AEAAPADDGM
     LHWRDSLVTP RVLPEEQLLQ KECEQAARWV AQRIADGTPP RQIMVLARRR NRLAAMQDAL
     RQRHIPVQQP EKNELHDAPE VQDVVALIDA LVSPAHDLSL ARALKSPLFG IGDDALVQLA
     LRQREQPSLS WFGLIQKGEG LPAELVEAGT RLKQWQRWLA GLPPHDALDA IFHDGDVLAR
     FGAAVPAPMR QSALANLRGL VAASLDIEGA RFATPYALVR ALRAGGVRAP SVAVPDAVQL
     LTVHGAKGLE ADTVLMLDCD APPPRAQTMG VLVEWKGSDT APTRFVFLAS EKTPPGCAAT
     LLEEEQRARH REELNGLYVA TTRARERLVL SSVQPARANE SSWWSRLESM CEPAEADEPL
     VVMPVESVVG SFSMKKMPVA PAVELPAIKK ANGGTVDARA AAFGQAMHRL LEWAVPGEAL
     PPAHVRAAAR EFMLDAPQAR GAAVLAERIR AGAGAWAWDE RMIDWHGNEV TLVHEGETLR
     IDRLVRERAS GAWWILDYKS AARPERDAEL IAQMQRYRAA VQHAYPGASV RVAFLTGQGE
     LVNLE
//