ID A0A1G8N7J3_9RHOB Unreviewed; 1157 AA.
AC A0A1G8N7J3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN04487993_1009205 {ECO:0000313|EMBL:SDI76269.1};
OS Salipiger marinus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Salipiger.
OX NCBI_TaxID=555512 {ECO:0000313|EMBL:SDI76269.1, ECO:0000313|Proteomes:UP000199093};
RN [1] {ECO:0000313|EMBL:SDI76269.1, ECO:0000313|Proteomes:UP000199093}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26424 {ECO:0000313|EMBL:SDI76269.1,
RC ECO:0000313|Proteomes:UP000199093};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; FNEJ01000009; SDI76269.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8N7J3; -.
DR STRING; 555512.SAMN04487993_1009205; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000199093; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000199093}.
FT DOMAIN 618..779
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 800..954
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1157 AA; 127462 MW; DA265CFF0B2F8C1E CRC64;
MVQSRILMGG APEGFDAKLI LSEVAKAAGP VLHVARDDKR LAALREALAF YAPAMPVVTF
PGWDCLPYDR VSPNPEICAT RMATLAGLVH GMPERFILLT TLSAVTQRLP ARAVLREAAF
SARVGSRIDE KALRNFLVRM GFVMAPTVTE PGDYAIRGGI IDIYPPGPGG PVRLDLFGDV
LDGARRFDAA SQRTTEKLDL VELAPVSEVI LDEPAITRFR QNYRIEFGAG GTDDPLYEAV
SAGRKAQGME HWLPFFHERL ETLFDYLPDA PVLLDDQLTP SRIARWDSIE DQYQTRRHAM
AQKGRMDTVY KPVPPGLLYL DDAAWEAAVA DRRVVQFHPL PQAPGPQVAD AGGRIGRSFA
PERQQESLSL FGALATHVKA KMQAGPVLIA SWSEGARERL TGLIEDEGLA EAIPVADATR
IGKRGLHLAV WGLEQGFEAP WGDPKDKLRI TVISEQDVLG DRLIRAPKKR RKAENFLTEA
QALTPGDLVV HVDHGIGRYQ GMEVITAAGA AHECLLLEYA EQARLYLPVE NIELLSRYGH
EDGLLDKLGG GAWQAKKARL KERIREMADK LIRVAAERAL RRAPVIDPPP GAWESFCARF
PYTETDDQLR AIEDVLADMT SGNPMDRLIC GDVGFGKTEV AMRAAFVAAM SGVQVAVIAP
TTLLARQHYK SFAERFRGFP LNVAPLSRFV SAGDAAKTRD GITKGTVDIA VGTHALLAKG
IRFKDLGLLI IDEEQHFGVG HKERLKELRT DIHVLTLTAT PIPRTLQLSL SGVRDLSIIG
TPPVDRLSIR TYVSEFDGIT IREALLREHY RGGQSFFVVP RLTDLPEIEA FLKEQVPEVS
YVVAHGQMAA GELDDRMNAF YDGRYDVLLA TTIVESGLDI PTANTMIVHR ADMFGLAQLY
QIRGRVGRSK TRAYAYLTTK PRAKLTDTAE KRLRVLGSLD TLGAGFTLAS QDLDIRGAGN
LLGEEQSGQM RDVGYELYQQ MLEEAIAKIR SGEGEGLLEE SGQWAPQINL GVPVLIPEEY
VPDLDVRLGL YRRLSELSTK VELEGFAAEL IDRFGKLPRE VNTLLLVVRI KDMCKKAGIA
RLDGGPKGAT IQFHNDRFAR PEALVTFLQD QKGDAKIKDN KVVIRRDWAS EGDKIKGAYA
IARDLAEKAG AIRLRKA
//
