ID   A0A1G8P1Z3_9NOCA        Unreviewed;      4370 AA.
AC   A0A1G8P1Z3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SDI86482.1};
GN   ORFNames=SAMN05444695_11237 {ECO:0000313|EMBL:SDI86482.1};
OS   Rhodococcus triatomae.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=300028 {ECO:0000313|EMBL:SDI86482.1, ECO:0000313|Proteomes:UP000183263};
RN   [1] {ECO:0000313|EMBL:SDI86482.1, ECO:0000313|Proteomes:UP000183263}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44892 {ECO:0000313|EMBL:SDI86482.1,
RC   ECO:0000313|Proteomes:UP000183263};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; FNDN01000012; SDI86482.1; -; Genomic_DNA.
DR   RefSeq; WP_072739103.1; NZ_FNDN01000012.1.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000183263; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 3.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 3.40.50.980; -; 6.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 3.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 3.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000183263}.
FT   DOMAIN          877..954
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1893..1966
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2957..3030
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4059..4134
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   4370 AA;  464803 MW;  959119F9C43DCF7E CRC64;
     MPGGTSDPEA SAHNEVDRIR WEAARRCRGM TDRALFTYAL LQLSPTRVWC VQLYHHLIVD
     GYSAAMISRR FADHYRSIVT DTPLRSKPFG AFADVVAEDL EYRESDRFAA DRDFWTTRFT
     PMPDLRVHAA PAGPAPDTVS AHTVLSAEAV QRLKEIATQH RCTWADVLIG GYAGYLSRLC
     GKRDVVLATP LMVRTTRTML TTPAMAVNVL PLHLRIDPTD RVADLARKAA AGMTELRRHQ
     RYRGADLIGD LGVPSAGALL HEAGINLKAF DVDLDFAGAR GTLRNVAGGP PEELGLTATP
     ISDGRLLLGF EADCRILTRE SVTARTDALR AVLDGLCDAA EPPIGTIDLR SDGGDPDWTP
     AAPPGHVAPL PTLFADLATR HRDDVVVDDG SAVTAGALAD RVYRIARVLR SRGIGPDDVV
     ALALPRTSDQ VAAMFAVWEA GAGYVVLDPD YPAERIAGLQ RRAAPAALIC TSQPPSPDAL
     PGTVIRLADE GTVAELAGFA PTPLSDRELA RPRHPDDLAY VLFTSGSTGE PKGVMVRSGG
     LSHLVHHHRH TLYADAAERA DGRRLRVAHT TSFAFDASLD PLLWILDGHR IHLYGTHVRQ
     DAHEQVRAFT EDAIDVVDTT PSMAALLVGA GLFDGPHRVG TLVVGGEALP ASLAARLAGS
     DVRAYNMYGP TEATVDAIGA TIDSGSPRIG KPLAGNSAYL LDAELRPVVD GEVGELYLAG
     PQLARGYLDR PGATADRFVA DPFGSGGRMY RTGDLVRWNH EDGYHFCGRS DDQVKIRGHR
     VELREVEAAL TRLPGVNSAA VVVDGTGPDA RLAGYVVAGK AASAKEIRRL LSTRVPAYLV
     PSTVQVLDEL PLTVNGKVDH ARLPAPADAS SAGEGAAPRT DAERVLCDVV AEVLGRTAVP
     VDTDFFTLGG DSIAAINVSS RLRGRGVILT PKQLLDQQDL ATVAASVATV SGAEDVDPRD
     VSTGVVPAPP AMRALLSAGT IDGHAQWRSV QFDVPLSEAR VVDAARAVLE HHPALRLVVT
     DPETVDVPVA GPDVAVDVLT AVAEHSAPAA AAEYARAAAG RLDPASGALL RIGLIPVTDG
     PDRLVVVVHR LGIDDSSWPL LLGDLSTACR SGLPDSRPGP SWRHWAADVA RRAAEGRYDD
     EESHWRAVTA LEPPAVVGTR SDGGPHLPAR LHRVHTDAAV VDAVLAGLPA RYRCRAQDVL
     AAALTVAIRS YLGDGTGDFP VWQTDEGRAA LYPDARPSVG WFAVDHPVAA PASLVASAPA
     AENAAAGGDV LAAVIRAVKA SRLAVRDAGL GYWALYGLPS GEARSTRAES PRIALRYRDD
     RWPPSDEGWH IARGEEGEFA PGGPEAFLTV EVRATRGVGP EDVLEVAWSA AGPRIDEPGL
     ASLHEHWDAA LQALLVHSCA TTGGLGVEDC PDLVVTQDRI REIEAENGPL AELWPLSPLQ
     GGLLAHTARF GPSSTYTLTA IVDLGGAVDG ARLHEAFATV VRRHPNLSAS FHHDRLEQPV
     QAVPREPSLH WEITDLRRVP AHAAEQAVTL IAERASARVF DITRSPLLAG HLIQLPEGEH
     RLVISAHHLV TDGWSTQVVL RELARVYNDG AEALAEPVGY GEHLQWLAHL DRGGLREAWR
     TRLAGLTRAT VVGGRGAPDH DGADRAVAEI EVTVATDLGE RLSAYRSTHG LTLNTLVQGA
     WSATLAAVTG HHDVLFGTPV SGRPEHLAGV EDMIGLFSNT VPVRVRLDDR PMLEVLRHCQ
     AEQFELGDAR QLGLSEIGAC SDIPFGEELF DTLVLFQNYP DLSDRGTGTG EDRLRIAGVR
     NLGSTQYPLS LVVPPGAEFR LVVNLDRNRI DDALVDFVTE QVPAVLERLA DALDAPATSF
     VPEVPFARGA SDAMRPSVPA FPDGSSVPPT DAAVAPDVLR AIGETFADVL DLEVEPDDDF
     FALGGHSLLA MRAVSKLRGA GLAVSVTDVF DARTPRAVAA RAVRTEPLPA APADEVAAPT
     EAGPQKLSDD SALSTAQERL WVLQELEGPS RTNDVPVVVQ FDGAVDPEAL AAAWRDLLGW
     HDILRTCYPP DESGAPGTLV LDVDAAGGLR TRHSGADLRA SVAEELTDPT KVIDIGSQCP
     SRATLLTGPG WNALVVVIHH IAIDGASIPI LLDHLAHAYA SRRDGTVPEN PASGPAYDVF
     VCDERRRGRA ADTRAGLRYW EQQLAGAPTE LDLPVDRSRP RDATHRSVRA VTPLSTELVA
     ALRGAVADRG VTPLMLLETA VAVTWHRYGT GADIPFGIAA SDREMIRDGA FEKAIGYFVN
     TVVHRLDLGG DPTLGELGLR VRRVGLDALG YQNVPFDRVV DALAPPRAAG RHPLFQTMVG
     HDVEVAPVEF GDVTGSLCEP VDPPARMDVA LWLVERRGGG FDLQITAAAD LFDPATVERI
     AGEVTAALDA VVTRPDTPLS GLLLTEPVSD PAVRVRTPDS VISRFYAHAR QRPDSPAIGS
     GGRVLTYRDA AGRVDSVARA LAAAGVRPGA VVGVAVDRDE WLPIALLAVL RCGAAYLPLD
     VDYPQERLQY MVDDARPTCV LTTTGQVQRL DWLRCPSIVL GEGPDGHEDV SLPPIPAAGD
     ALAYIIHTSG TTGNPKGIMV TTANLAAFAA TVGEYGLLSA DDRILALTTV SFDMATLELM
     SPFAVGAFVE IVPRAEVVDP ERLAAVIAAT EPTVLQATPS LWRMLIAEPA LPDLGGIRGL
     VGGEAVPAEL AAQMAARCGQ VWNMYGPTEV TVWATAGVLT PDGPVTIGGP WTDVRARVLD
     DLLRPVPDGG IGELYLGGTQ VVRGYLNRAG MTATRFVPDP DAPGRRLYRT GDVVRRRGPH
     LEYLRRADDQ VKVRGFRIEL GEVETALRAL PGVRDAAAKV IRSADDSGRL VGYVVPGDGV
     TPDVADLRRR LIDNLPQYLV PQSISMIDAL PTTLNGKLDR ARLPEPVAAS RTRARPAEGT
     DALGEAGARG ALGAPQPRPR STLALVCTTV EDILGVPATA DDEFFALGGD SIGAVRLVAA
     LRKSGLSLAV ADVFDAVPLS VLAATTVRAA PDADPLVRDG VLVELDTRAA ARLREDYPQW
     EQVLPLGPLQ EGMYFQSLSD RAATGLDSYH VQYCFDFPAQ APCDLAALES ATAALLRRYP
     NLRAGFTHQG FDAPVQIVTP AVVPVEVGPV DTDTEIAEWA TRSFEEPFDL ARPPLLRITV
     AERRDGSQQV ILTHHHLLTD GWSQAVMLSE LFTLYGVARA LAPVGAADPS GSAAWIGGKL
     DEVLDPPADY TDHLRWLRST DTEAAAAAWG DYLSGLTEPT LVAEEAPTGL MLPNRQSTVV
     APDVLAGLQA LARECGVTLS TVMAVAWGLV LRRVTGRDDV VFGTTVSGRD PSVPDVGRIV
     GLTLNTVPTR MRLAPGLPLA ELLSTTMREQ GRLTAHHHLG LGRINRTTGL SVLFDSLYVF
     RNLNGPEVIR TGRAAVFDRA GIVGSQAKDA THYAVTVDVD PASADGDCRI TVENRPDLVA
     DDDARRLLDV MGEVLGLMGR AGAREVVVAD TGTALAGTDG TDGDLAPLIP ELVDVPAPGQ
     AGGSIDTLLV ERAALTPDAP ALTCGAVTLT AAQLHARTDA MARELAGRGV GPGDVVALAL
     PRIADHVVAI FAVMRAGAAY LPLDLGYPAQ RLTELVTDSE AGTLITHDAA TGRSREIVAG
     LVGVDIVDLA HPSVAAVLDG RVAPPTVADE QVSGPRYEDQ LAYVIYTSGS TGKPKGVQVP
     HRGLTTMYHN HRDEIFLPTE DSVGGRRLRV AHTVSFSFDM SWEELFWMLA GHHVHVIDEE
     FRLNPVALVQ HYREIGIDVI NVTPSYAREL LSGGLLDDER RPVLVMLGGE GVPQELWSLL
     RDTDGVDGYD LYGPTEFTIN AMGSAVRDSA SPCLGRPVRN AHARVLDSGL KPVPVGAAGE
     LYLSGDGIAQ GYLGRAGTTA ATFVANPYRP GSRMYRTGDV VRLRAGGRLE YLGRADHQVK
     IRGIRIELGD VEAALESIPG IARAAATVRE QGPTKKLVGY VVPDAGSPPV DVRSELRDRV
     PAHLIPAEIV TIESVPLTVN GKLDRAALPA PPRRDAADTL RTPSQQRVAS VFGAVLGVDG
     VGADDSFFDC GGDSLTAMRL MTALHREFGV DVDVATLLRR PTVADIAAHV DARDPDSSPV
     QGGTDPGGTE DVLVLRDGGA GGPLWCVHPA GGLAWQFAPL AAALPGDRPV LGLQLPATTT
     ARVVDDLARE YLRTVRDRQP TGPYRLLGYS FGGNVAHAMA ELLAESGEDV AFLGVLDAYP
     AGVDLSAARK GSVRPEQDLE GVPEELGRAL QANFSRTVSM LDATTRTPEY RGALTLFAAN
     ASGRGEVMVE LWREHHRGEL TVHRLDHDHG SIVGRDGWAE LVPLLESAVE
//