ID A0A1G8RPL4_9FIRM Unreviewed; 567 AA.
AC A0A1G8RPL4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=SAMN04487760_103172 {ECO:0000313|EMBL:SDJ18842.1};
OS Lachnospiraceae bacterium G41.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1200749 {ECO:0000313|EMBL:SDJ18842.1, ECO:0000313|Proteomes:UP000199016};
RN [1] {ECO:0000313|EMBL:SDJ18842.1, ECO:0000313|Proteomes:UP000199016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G41 {ECO:0000313|EMBL:SDJ18842.1,
RC ECO:0000313|Proteomes:UP000199016};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNEU01000003; SDJ18842.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8RPL4; -.
DR STRING; 1200749.SAMN04487760_103172; -.
DR OrthoDB; 9762826at2; -.
DR Proteomes; UP000199016; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45453; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR PANTHER; PTHR45453:SF1; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:SDJ18842.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000199016};
KW Transferase {ECO:0000313|EMBL:SDJ18842.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..567
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 567 AA; 64747 MW; 46E5FC15986D608F CRC64;
MAKNKRKNFI QVFIPKFLIS IPIVIIVFII TVTFMNMRSE SELERNNEIY SDSRIKNIEE
YLHEYSFAEK QDLIGLNLRL YQSSSVFAWP GYKSIAYVED ANGEVVLDSE KAIQILIIDR
DLGITNRLTD VYTCDLDYLN SYPEFADLLR RDEAYISDTV LEFLLPRKIV DSHPIILTGY
ADPDTHKFYV GKCVFPYYET KMFLGYESEE ELYENYIKKV ETDLTPADVS GYLEYNAVSD
SASIPDENST TRYFDGKLIS SFTLLCGGKE SVKDVTSKVT YLDHLSHISK QIKDASGNTY
TVHFMLSDNF TKAYMSVMIL LALIYLFIDT GICLLISKIS YEKLKGFYRN EDYRKALMSS
MAHDLKTPLT VMSGYAENLK ENVQTKKREH YADAILENTN YMNGIITDVL GLAKLEEETA
KNKVEKLDFC EIAKAQAERI KPLLEERNIT LTVDGSFNRN ADRASLERVM DNLLSNAAKY
TKEGGNVNVY AKDKPFSKHV FVIENTPIDA IDVKPSKLWE PFVKGDPSRS DKNGTGLGLS
IVKNILDNLG FKSKIKIKDG WFRVIIK
//
