ID   A0A1G8RQH0_9RHOB        Unreviewed;       489 AA.
AC   A0A1G8RQH0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Mannitol 2-dehydrogenase {ECO:0000313|EMBL:SDJ19314.1};
GN   ORFNames=SAMN04488026_101386 {ECO:0000313|EMBL:SDJ19314.1};
OS   Aliiruegeria lutimaris.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Aliiruegeria.
OX   NCBI_TaxID=571298 {ECO:0000313|EMBL:SDJ19314.1, ECO:0000313|Proteomes:UP000199382};
RN   [1] {ECO:0000313|EMBL:SDJ19314.1, ECO:0000313|Proteomes:UP000199382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25294 {ECO:0000313|EMBL:SDJ19314.1,
RC   ECO:0000313|Proteomes:UP000199382};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FNEK01000013; SDJ19314.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G8RQH0; -.
DR   STRING; 571298.SAMN04488026_101386; -.
DR   OrthoDB; 271711at2; -.
DR   Proteomes; UP000199382; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0019594; P:mannitol metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR023027; Mannitol_DH_CS.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43362:SF1; MANNITOL DEHYDROGENASE 2-RELATED; 1.
DR   PANTHER; PTHR43362; MANNITOL DEHYDROGENASE DSF1-RELATED; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199382}.
FT   DOMAIN          28..191
FT                   /note="Mannitol dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01232"
FT   DOMAIN          220..462
FT                   /note="Mannitol dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08125"
SQ   SEQUENCE   489 AA;  53099 MW;  B89B601C4BE0BAB1 CRC64;
     MKLNAQTLSQ LDPRIAVPSY DRSQLKPGIL HVGLGNFHRA HQAFYANQLL NTGGSPDWGI
     LGAGVMPTDA AMRADLEAQD WLYSVTKQGA GTEEVEVSGV MCGFLPVEEG HGPIIEAMQN
     PDVRIVSLTV TEGGYYVSAE TGGFNPEAPD IRADIASPDK PKTVFGAIVA GLKARRDAGQ
     VPFTVMSCDN LPHNGNVTRS AVVGVARGQD GALADWIDAN VAFPNAMVDR ITPATTSERA
     AGLAEEYGLE DARPVFCEPF LQWVLEDNFT AGRPAFEEVG VQIVEDVTPY EHMKIRMLNG
     GHAIIAYPSA LLGLTYAHEA MAHPLVSAFF DKVEREEIYN VVEAVPGATQ PEYHAALQER
     FANPAIRDTI ARLCFDGSNR QPKFIVPSVA ENLAQGRSVP GLALESALWC RYCFGEGEQH
     QEIAANDPSW DRLTGLAREA RDRPAAWLEM RDIYGDLAEK PDFRDAFAAA LESLWSKGCE
     ATLKAYLGL
//