ID A0A1G8VEQ7_9GAMM Unreviewed; 809 AA.
AC A0A1G8VEQ7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=SAMN04487954_106187 {ECO:0000313|EMBL:SDJ64571.1};
OS Halomonas gudaonensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=376427 {ECO:0000313|EMBL:SDJ64571.1, ECO:0000313|Proteomes:UP000198525};
RN [1] {ECO:0000313|EMBL:SDJ64571.1, ECO:0000313|Proteomes:UP000198525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6133 {ECO:0000313|EMBL:SDJ64571.1,
RC ECO:0000313|Proteomes:UP000198525};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; FNES01000006; SDJ64571.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8VEQ7; -.
DR STRING; 376427.SAMN04487954_106187; -.
DR Proteomes; UP000198525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000198525};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 560..755
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT REGION 786..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 224..274
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 693
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 809 AA; 88966 MW; 543126A2082E4E6B CRC64;
MDAQDSMSPL SVAQIYRACP EDLFDFEVTS ELGSLDLLSS HRRARDALDF GTAMRSEGFN
LFVLGQPGHG MHDMTGRFLA ERSHHEPTPP DIAYRYNFDD PARPCYLSLP TGTGRVLSAD
LDNLVDELRT AIPAVFESDE YQNRLHELKQ AMGERQRDAI EAVRREAREH DILLLSTPNG
FTFAPAADDD KMMSPEDFQK LPDDDRERIE GTVAILQKKL TAAIRRMPRL AKQLREQVDA
LNEEMLESAI GTPLEELEER YANHEGVLAH LTAIREAILA HVGSFIEDEP DIPPEAVFSR
CHLNLIVDNQ GTDGAPVVYL DLPSHQHLVG RIEHHVHNGT LLTDFSLIRA GGLHRANGGY
LVLDARTLLT QPGAWETLKR VLRAGEIRTE SLEQAYGLIS TTTLEPEPVP LDLKVVLLGE
RLLYYLLCEH DPDFLELFKV QADLEDDLPR NDENLPLFAR MLATQAREAA LRPLDRSGVA
AVMERASRLA DDQRKLTARH RALGDLLQEA DHWAGQASAA VIAREHVEKA VSQQLWRAGR
LRERSFEQIV RGTLAIRTEG HEVGQVNGLS VLTLGDFAFG QPTRITATAR PGAGQVVDIE
REARLGGRIH SKAVMILSRC LAGRYAPDTP LSLSASLAFE QSYGGVEGDS ASVAEACALI
SAIARAGIDQ RLAVTGSIDQ YGRVQAVGGV NEKIEGFFEI CRARGELNGH GVLLPTTNVE
QLMLGNEVRE AVADGRFRLY AIADLDQALT LLTGLPLGEA DSEGRYPAGT LNAGVMERLA
AFHEAVKRKA EGNDGDEGGQ DEEVDDHDG
//
