ID A0A1G8VKB5_9GAMM Unreviewed; 212 AA.
AC A0A1G8VKB5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE RecName: Full=Chloramphenicol acetyltransferase {ECO:0000256|ARBA:ARBA00020291};
DE EC=2.3.1.28 {ECO:0000256|ARBA:ARBA00013235};
GN ORFNames=SAMN04488540_11174 {ECO:0000313|EMBL:SDJ66423.1};
OS Ferrimonas sediminum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Ferrimonadaceae; Ferrimonas.
OX NCBI_TaxID=718193 {ECO:0000313|EMBL:SDJ66423.1, ECO:0000313|Proteomes:UP000199527};
RN [1] {ECO:0000313|EMBL:SDJ66423.1, ECO:0000313|Proteomes:UP000199527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23317 {ECO:0000313|EMBL:SDJ66423.1,
RC ECO:0000313|Proteomes:UP000199527};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate +
CC CoA; Xref=Rhea:RHEA:18421, ChEBI:CHEBI:16730, ChEBI:CHEBI:17698,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.28;
CC Evidence={ECO:0000256|ARBA:ARBA00036833};
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNEM01000011; SDJ66423.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8VKB5; -.
DR OrthoDB; 9815592at2; -.
DR Proteomes; UP000199527; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd03349; LbH_XAT; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR43300; ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR43300:SF12; CHLORAMPHENICOL ACETYLTRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SDJ66423.1}.
SQ SEQUENCE 212 AA; 23968 MW; E9A314DDD39D95D8 CRC64;
MTENQKHWTR FELLHQTVQN PHIHITGTRS YYSDFWDEGF ERSVVRYLHG DEQTRDRLPP
WPVDQLYIGD CVCIGAEAVI LMGGNHTHRT DWFCLYPFME HITEAYQGKG DTHIGSGAWI
GMRAMIMPGV TLGEGAVVAA NSVVTRSVPP YTVVGGSPAK VIKTRFEQPV IERLLALGIY
EWDEAKFETL KPLLCNNDID ALETALSAYE AR
//
