ID A0A1G8VUM5_9EURY Unreviewed; 370 AA.
AC A0A1G8VUM5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Probable porphobilinogen deaminase {ECO:0000256|ARBA:ARBA00021723};
DE EC=2.5.1.61 {ECO:0000256|ARBA:ARBA00012655};
GN ORFNames=SAMN05216226_107176 {ECO:0000313|EMBL:SDJ69719.1};
OS Halovenus aranensis.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Halovenus.
OX NCBI_TaxID=890420 {ECO:0000313|EMBL:SDJ69719.1, ECO:0000313|Proteomes:UP000198856};
RN [1] {ECO:0000313|EMBL:SDJ69719.1, ECO:0000313|Proteomes:UP000198856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBRC-M10015 {ECO:0000313|EMBL:SDJ69719.1,
RC ECO:0000313|Proteomes:UP000198856};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=dipyrromethane; Xref=ChEBI:CHEBI:60342;
CC Evidence={ECO:0000256|ARBA:ARBA00001916};
CC -!- SIMILARITY: Belongs to the HMBS family.
CC {ECO:0000256|ARBA:ARBA00005638}.
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DR EMBL; FNFC01000007; SDJ69719.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8VUM5; -.
DR STRING; 890420.SAMN05216226_107176; -.
DR OrthoDB; 8042at2157; -.
DR Proteomes; UP000198856; Unassembled WGS sequence.
DR GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR Gene3D; 3.30.160.40; Porphobilinogen deaminase, C-terminal domain; 1.
DR InterPro; IPR000860; HemC.
DR InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR InterPro; IPR022417; Porphobilin_deaminase_N.
DR InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR InterPro; IPR036803; Porphobilinogen_deaminase_C_sf.
DR NCBIfam; TIGR00212; hemC; 1.
DR PANTHER; PTHR11557; PORPHOBILINOGEN DEAMINASE; 1.
DR PANTHER; PTHR11557:SF0; PORPHOBILINOGEN DEAMINASE; 1.
DR Pfam; PF01379; Porphobil_deam; 2.
DR Pfam; PF03900; Porphobil_deamC; 1.
DR PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 2.
DR PRINTS; PR00151; PORPHBDMNASE.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR SUPFAM; SSF54782; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain; 1.
DR PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE 3: Inferred from homology;
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000198856};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..159
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 212..262
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 279..325
FT /note="Porphobilinogen deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03900"
FT REGION 169..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 40286 MW; 1C57DCC41FDFDDF8 CRC64;
MSTHGTLQLA TRGSALARWQ AETVRDQLSS RRQPVELVTV ETEGDQVRDE LIHQLGTTGA
FVRSLDEQVL SGDLNAAVHS MKDMPTEQPD DLIVAGVLER GPPGDVLVTP EGTSLEDLPE
GATIGTSSLR RGAQLLARRP DLDIAGLRGN VDTRVEKLLG PELQREHDRR VEAWHNETDD
DENEDKSEFD RPPEEWVESL TALEQAALDR EVETEYDAIC LAEAGLDRSS LLGELHVEHL
DPESFVPAPA QGVIAVTALD DEAAEYIHDT VDDPPTRVET TVERTVLAEL GGGCVAPVGI
YARLQGDVVS TRVRVLSQDG TEEVSDARDL PVERHAQAAA EFAADLADRG AADLIEKARR
EDPDDAKRGE
//
