ID A0A1G8WFI0_9FIRM Unreviewed; 361 AA.
AC A0A1G8WFI0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:SDJ77054.1};
GN ORFNames=SAMN04487760_11445 {ECO:0000313|EMBL:SDJ77054.1};
OS Lachnospiraceae bacterium G41.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1200749 {ECO:0000313|EMBL:SDJ77054.1, ECO:0000313|Proteomes:UP000199016};
RN [1] {ECO:0000313|EMBL:SDJ77054.1, ECO:0000313|Proteomes:UP000199016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G41 {ECO:0000313|EMBL:SDJ77054.1,
RC ECO:0000313|Proteomes:UP000199016};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FNEU01000014; SDJ77054.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8WFI0; -.
DR STRING; 1200749.SAMN04487760_11445; -.
DR OrthoDB; 9805684at2; -.
DR Proteomes; UP000199016; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR NCBIfam; TIGR00978; asd_EA; 1.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199016}.
FT DOMAIN 6..138
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 158
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 251
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 361 AA; 40623 MW; E5FD72010C148041 CRC64;
MSDKLRVGIL GGTGMVGQRF ISLLENHPWF EVVLIAASPR SKGKRYEEAV GDRWKMSTPM
PEAVKDMIVY DVNEVEEISS KVDFCFSAVD MTKDEIRAIE EAYAKAETPV VSNNSAHRWT
KDVPMVVPEI NPEHMKVIED QKKRLGTKRG FIAVKPNCSI QSYAPVLTAW KEFEPYEVIV
STYQAISGAG KTFKDWPEMV ENIIPYIGGE EEKSEKEPLR IWGKVENGEI VPADNIKITS
QCIRVPVLNG HTASVFVKFK KQPTKEQLIQ KLWDFKGLPQ ELNLPSAPKQ FIQYLEEDNR
PQVALDVDYE RGMGISVGRI REDSIYDWKF VGLSHNTVRG AAGGAILCAE LLKAQGYISA
K
//