ID A0A1G8WGJ5_9BACI Unreviewed; 491 AA.
AC A0A1G8WGJ5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Na+:H+ antiporter, NhaC family {ECO:0000313|EMBL:SDJ77444.1};
GN ORFNames=SAMN05216243_0793 {ECO:0000313|EMBL:SDJ77444.1};
OS Sediminibacillus albus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Sediminibacillus.
OX NCBI_TaxID=407036 {ECO:0000313|EMBL:SDJ77444.1, ECO:0000313|Proteomes:UP000198694};
RN [1] {ECO:0000313|EMBL:SDJ77444.1, ECO:0000313|Proteomes:UP000198694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.6502 {ECO:0000313|EMBL:SDJ77444.1,
RC ECO:0000313|Proteomes:UP000198694};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
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DR EMBL; FNFL01000001; SDJ77444.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G8WGJ5; -.
DR STRING; 407036.SAMN05216243_0793; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000198694; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF3; MALATE-2H(+)_NA(+)-LACTATE ANTIPORTER; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198694};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..464
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 491 AA; 52504 MW; A5CD1F00BAAFEAD2 CRC64;
MNQAEIRRPS IGMALVPILI ALAVFIIGIG VLKYQAELML IFAGAIFAVF AVFHGHSWEK
ILVVMGDKIK KALPAILILF SIGLLIGTWM ISGTIPFFVY YGLEIINPSY LYVMAFIVTA
IVSTCVGTSW GSAGTIGVAL MSIAQTMDLS LAVTAGAVVS GAYFGDKLSP LSDTTNMSSL
AAGSNLYEHI RHMLYTSIPS SVIAIIVFYF VGLKIDSNPA QLTNVEEMLS GIGQLFNLNV
VVLIPAVIVI AGSLMKKSPL IVLFVSALSA MAIALFFQNA SVSNLFTAAV EGFHVDMLAA
AIPGLDAGII SEDMQGLLNR GGLYSMYGAT FFVFCAFFFA SALEVSQALN VILEKMITYL
KSVGSVIFAS LLTGFAVINC TSNALVTYFL VQDIYGDVYK KKNLHPVNLS RSMEDSVTIT
EALMPWTVSG VFMATTLGVG NFEFLPWAIF NLGGIIFSAL YGFLAPYTGG FGIRTNEPEA
ETGNTSSKTA I
//
