ID   A0A1G9BJK1_9CLOT        Unreviewed;      1121 AA.
AC   A0A1G9BJK1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=SAMN05660472_01193 {ECO:0000313|EMBL:SDK39637.1};
OS   Natronincola ferrireducens.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Natronincola.
OX   NCBI_TaxID=393762 {ECO:0000313|EMBL:SDK39637.1, ECO:0000313|Proteomes:UP000198718};
RN   [1] {ECO:0000313|EMBL:SDK39637.1, ECO:0000313|Proteomes:UP000198718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18346 {ECO:0000313|EMBL:SDK39637.1,
RC   ECO:0000313|Proteomes:UP000198718};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; FNFP01000002; SDK39637.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9BJK1; -.
DR   STRING; 393762.SAMN05660472_01193; -.
DR   OrthoDB; 32195at2; -.
DR   Proteomes; UP000198718; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR047939; BREX_1_PglX.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SDK39637.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198718};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SDK39637.1}.
FT   DOMAIN          482..625
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   1121 AA;  130667 MW;  1605989FB95B3729 CRC64;
     MDKNVLKSFA IRGRQKMING IMKRAQQLGV TKDEIKKMKL SENGFILDEK DNNIVLKQYQ
     FKQRQQLVGR IKEKGFEEVI EEAAYIWFNG LIALRFMEVK GYLPTGVRVL SSIEEGKKEP
     DIIRAALHID LDLNREIVTS LIKEKDIEDL YRYLLVRQCN QLGKIIPTIF QRIRGYIELL
     LPDDLLARGS IIDDLVFSVK EEAFREGIEV IGWLYQYYIS QEKDEVFAGV NKNQKIMKEN
     IPAATQIFTP KWIVQYMVEN SLGKLWRDIN PDTKLISKWR YYLDEGHQGI EVKQQRYAPG
     NKKLTPEDIK LLDPAMGSGH ILVYAFDLLY DIYLEAGYRE EDISKLILEK NLYGLDIDDK
     VTPLTSFALM MQARSKTPDI FDKKVSLNIY AIQESIDISQ EAMDFFIAPQ KDLKDEVQYL
     MDIFQNAKEY GAMLEVKKIN FDAIEGRIEE IREADIEDLF MLEYREAILK TIPPLVKQGR
     LMSDKYDVVV ANPPYGGLRK LNPNLKRFLE DNYKDYKYDL FSVFIIRNLS FTKEYGYTGF
     MTPNVWQFIN SYEKLRRVIM NNYQLDSLIQ LEDEGFQDAS VSISTFIINK CPLFKKAIFI
     KLQARGDVQA QRAEEAIKSK DGNKYVVEPT IFNDIPNHKI AFWISSSTLD TFKRGEKLET
     IGKPRQGMAT SDNNRFLKYW YEVSFPTIKF GATSSNDTAG YKWIPYNKGG GHRKWYGNND
     MVINWEKNGY EVKKYAAQLY GNYSRTIKNE GLYFKEGITY TFIGKDMAPR LSPKGFIFDV
     AGSMIFVEEE WIFYILALIS TNLSRHYMDI LNPTINIQVG DIKNIPVIKT EDRKTLEKIN
     RLALENIDIA KKHWDSFETS WDFEKHPFLI HRHNTCYIKE AYNQWESFTE NQFNRLKANE
     EVLNKMFIEI YGLQDVLTPE VEEKEITIKK ANRERDIKSL ISYAVGCMFG RYSLDADGLV
     YGGGDFNINQ YKSLQASKNN IVPIVENESF EGDITNRFEA FLIATFGQEA IEGNLTYIAE
     TLGMKSNETS RQTIKRYFQK YFYKDHIKTY NKRPIYWLFN SKDTCDFKVL TYIHRHNELM
     MSIENRELRI DIDDGILTNY RGLQGKEVNL GQGKYLLAAI E
//