ID A0A1G9EQJ6_9PROT Unreviewed; 378 AA.
AC A0A1G9EQJ6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:SDK78409.1};
GN ORFNames=SAMN05192566_2398 {ECO:0000313|EMBL:SDK78409.1};
OS Methylophilus rhizosphaerae.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylophilus.
OX NCBI_TaxID=492660 {ECO:0000313|EMBL:SDK78409.1, ECO:0000313|Proteomes:UP000198629};
RN [1] {ECO:0000313|EMBL:SDK78409.1, ECO:0000313|Proteomes:UP000198629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBMB127 {ECO:0000313|EMBL:SDK78409.1,
RC ECO:0000313|Proteomes:UP000198629};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; FNFX01000005; SDK78409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9EQJ6; -.
DR STRING; 492660.SAMN05192566_2398; -.
DR OrthoDB; 9775207at2; -.
DR Proteomes; UP000198629; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30566:SF25; INNER MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR30566; YNAI-RELATED MECHANOSENSITIVE ION CHANNEL; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 140..181
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 182..249
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 255..338
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 353..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 41984 MW; 464FB0D0297F4F7A CRC64;
MPDWLAAQTL LGIPLYEWLY AALISAVIYL VLYNLWQISI KKLSGIAQRT ATRLDDVVLE
VLQGTHQLTI LLLSLLFGLH VLELPLKWET RLDHVSFIVI GIQVAVWLNR GVGIWARDHI
AAINGPTPAV NPVITSVLSW IFRIAIWSVL LLTILANVGI NITAFVASLG VGGVAVALAV
QNILGDLFAS LAIGLDKPFE VGDFIVFGEV AGAIERVGLK TTRIRSISGE QIICSNTELL
KNTIHNYKRM EERRVVFNFN VNYATPPDMI AQIPGIVRQA IESFDNTRFD RSHFKEFGAS
ALVFETVYFI TTTDFNLFMD IQQAVNLYLM KEFHAHKVLF AFNTMTLNVP DLQPDNSHTG
LNGSSGESTT GKRQQAKH
//
