ID A0A1G9P872_9SPHI Unreviewed; 743 AA.
AC A0A1G9P872;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:SDL94988.1};
GN ORFNames=SAMN05421813_10428 {ECO:0000313|EMBL:SDL94988.1};
OS Daejeonella rubra.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Daejeonella.
OX NCBI_TaxID=990371 {ECO:0000313|EMBL:SDL94988.1, ECO:0000313|Proteomes:UP000199226};
RN [1] {ECO:0000313|Proteomes:UP000199226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24536 {ECO:0000313|Proteomes:UP000199226};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FNHH01000004; SDL94988.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9P872; -.
DR STRING; 990371.SAMN05421813_10428; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000199226; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:SDL94988.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199226};
KW Transferase {ECO:0000313|EMBL:SDL94988.1}.
FT DOMAIN 60..159
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 403..464
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 743 AA; 84755 MW; BD47C0C042820FC0 CRC64;
MKELVIDIEA EKKEILKRYR ALLRACKSTM QKGDKRMIRL AFDMALASHQ NMRRKSGEPY
IYHPIAVAQI AAEEIGLGTT SIVCALLHDV VEDTDITLDD IEREFGKKVA KIIDGLTKIS
GVFDYNSSLQ AENFRKMLLT LADDVRVILI KLADRLHNMR TMDFMPRDKQ LKISSETVYL
YAPLAHRLGL YTLKSELEDL AMKYMEPVTY KFIAQQLNEK KAERENFIRD FITPIKEILN
EQGLDADLYG RPKSIHSIWT KMRKKNIPFD EVYDLFAIRI ILNSKPESEK SDCWKAYSIV
TDLYRPNPDR LRDWISSPRA NGYESLHTTV MGPRGQWVEV QIRTNRMNEI AEKGFAAHWK
YKEEPNTDSG LDQWIHKVRE LLSNPEANAL DFLDDFKMNL FSDEIFIFTP KGALIQLPVE
ATALDFAFEI HTDIGASCIG AKVNHKLVPL SHKLQNGDQV EIITSGKQSP KEDWLSFVVT
AKAKSKIKSS LKEEKRKIAE QGKEILERKL KSLKVTYNTD NLYKLSYYFK LSSTLDLFYN
VAQGKIDVKQ LKEFVASEKV VENKPEKIDN GYNEQLIKKV KGDDNDTLLI GEDLQKLDYK
LSSCCNPIPG DDVFGFVTVG DGIKIHRTNC PNAAKLMSNY GYRIVKARWN SQKELAFLTG
LHITGIDDVG LINKITTVIS SDFKVNMRSI TVDTDNGIFE GSIMVYVNNT KHLDNLINKL
KEVVGVTSVT RFDSNPEDLV KAS
//
