ID A0A1G9PF35_9ACTN Unreviewed; 398 AA.
AC A0A1G9PF35;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
GN ORFNames=SAMN05660642_01201 {ECO:0000313|EMBL:SDL97436.1};
OS Geodermatophilus siccatus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Geodermatophilus.
OX NCBI_TaxID=1137991 {ECO:0000313|EMBL:SDL97436.1, ECO:0000313|Proteomes:UP000198680};
RN [1] {ECO:0000313|EMBL:SDL97436.1, ECO:0000313|Proteomes:UP000198680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45419 {ECO:0000313|EMBL:SDL97436.1,
RC ECO:0000313|Proteomes:UP000198680};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
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DR EMBL; FNHE01000003; SDL97436.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9PF35; -.
DR STRING; 1137991.SAMN05660642_01201; -.
DR OrthoDB; 729130at2; -.
DR Proteomes; UP000198680; Unassembled WGS sequence.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:InterPro.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 227..332
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
SQ SEQUENCE 398 AA; 42323 MW; 9AC182C533C22C0E CRC64;
MAVVGLGGAV ATTAVAGLEL LRNGTGDTTG LPLAGLEVEG RPLEEVTGMA GYADLVVGGW
DLDGTDLRKA AELHGVLDPH QLEQAGPHLS SVTPWPAAGD ADFCRNVTGG NVVLAETRRA
QVDAVRADLR RFREEHDLDG LVLVNLASTE RWPDPEAPAL QTVEAFEAGL DADDRAITPA
MVYAYAAIAE GVGYVNFTPS LAADVPALVA LAGSRGVPVA GKDGKTGQTM LKTVLAPAFR
SRSLTVEGWY STNILGNRDG QALDDPDSLA SKLNTKGSVL DSILGYPVED HVVRIDYYRP
RGDQKEAWDA IDLVGFLGQR MQVKVDFQCR DSILAAPLAI ELARLTDLAQ QRGEGGVQTQ
FGWFFKAPMS PDGSTPEHAL HRQERVLLDW VAGAPAGR
//
