ID A0A1G9RPT9_9SPHI Unreviewed; 1118 AA.
AC A0A1G9RPT9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=SAMN05421813_108107 {ECO:0000313|EMBL:SDM25276.1};
OS Daejeonella rubra.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Daejeonella.
OX NCBI_TaxID=990371 {ECO:0000313|EMBL:SDM25276.1, ECO:0000313|Proteomes:UP000199226};
RN [1] {ECO:0000313|Proteomes:UP000199226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24536 {ECO:0000313|Proteomes:UP000199226};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; FNHH01000008; SDM25276.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9RPT9; -.
DR STRING; 990371.SAMN05421813_108107; -.
DR Proteomes; UP000199226; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SDM25276.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000199226}.
FT DOMAIN 575..736
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 757..911
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1118 AA; 128071 MW; 7E2D3B22BFCE6DD1 CRC64;
MNIRDILIQY KSDPRIAILA ETLNKGRKTR VHLKGLIGSS DSVIAIATYF LLHRHMIFVL
PEREEAAYFL SDLESLLEKE VLFFPSSFRK SFEFTQVDSS NVLQRAEVLN ELNHASEFGK
IIVTYPEALA EKVIDRQALE KNTLEISVGN KLSIEFINEF LIEYDFDRVD FVYEPGQFSV
RGGIVDIFSF SHDLPYRIEF FADYIESIRT FEIEDQLSVE QVKSITVVPN VQSKFLTDHN
ISLLEYIDQD SIIWFKDVEF TLDIVKTGFK KAVEFWNALA AEDKKQNPQW IDPKFNFTDE
KMLADQLKDF DLLEFGKQFF YEADETIQFD TKPQPSFNKD FNLLIHNFKE NEKAGVENLI
FTDSTKQIER LYSIFEDLKA GIQFKPIHLS LREGFIDHGQ KLACYTDHQI FDRYYKYKLK
KGYIRSQAIT LKELRDLKPG DFITHIDHGI GKYAGLEKVD VNGRSQEMIR LVYADNDLLY
VNINSLNRIS KYSGKEGTVP RMNKLGTDTW EKLKKTTKKK VKDIARDLIK LYAIRKSQTG
TAFLPDTYLQ TELEASFIYE DTPDQVKATA DVKKDMESAH PMDRLVCGDV GFGKTEIAIR
AAFKAVTDSK QVAILVPTTI LALQHFKTFT SRLKDFPCNI DYINRFKSAK QIRETLEKLA
QGKVDIIIGT HRIVSKDVKF KDLGLLIIDE EQKFGVGVKE KLKQFRANVD TLTLTATPIP
RTLHFSLMGA RDLSIISTPP PNRQPVVTEL HVFNEKLIKE AVEFEIDRGG QIFFIHNRVQ
DLMQLGGLIN TLVPKARIGI AHGQLEGDAL EDVMLKFVGG EYDVLVATTI IEAGLDIANA
NTILINHAHM FGLSDLHQMR GRVGRSNKKA FCYLLSPPLS TLTNEARKRL SAIEEFSDLG
SGFNVAMRDL DIRGSGNLLG AEQSGFIAEI GFEMYHKILD EAIQELKDDE FKNLFSDEKP
RPFISFTHVD TDLEVMIPDE YVTNIAERYN LYTELSNIED ELALDAFRQK MADRFGPVPQ
QVIELINTWR LQHLGKMIGF EKISFKKGVL RGYFLTNKQS AYFETEQFGR VLSFLQAHPR
ISNLKEVKNT LRLAIEHVQT LDIAIEMLQE IALIPEKI
//
