ID A0A1G9S322_9ACTN Unreviewed; 700 AA.
AC A0A1G9S322;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SDM29680.1};
GN ORFNames=SAMN05444921_106135 {ECO:0000313|EMBL:SDM29680.1};
OS Streptomyces wuyuanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1196353 {ECO:0000313|EMBL:SDM29680.1, ECO:0000313|Proteomes:UP000199063};
RN [1] {ECO:0000313|Proteomes:UP000199063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.7042 {ECO:0000313|Proteomes:UP000199063};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; FNHI01000006; SDM29680.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9S322; -.
DR STRING; 1196353.SAMN05444921_106135; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000199063; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199063};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 172..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 232..327
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 540..666
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 700 AA; 73551 MW; 6E20DED295B735EE CRC64;
MNALLTRVAT APGGRRTKWL VLAAWLLLAV ALGPLAGRLG EVEDTGANAF LPRGAESARV
NTELERFRTD TIMPAVVVYT GDGARAKAEA DRAAFAGFAA EGERVAPPLP SDDGQALMTV
VPLSTEEDGL TGTVDEMRRI AGEGAPPGVR AEVGGPAGSL TDQVAVFDSL DSTLMIATGL
VVAVLLLVTY RSPVLWLFPL LAVGFAAVLT QVGTYLLARY AQLPVDPQSA GILMVLVFGV
GTDYALLLIA RYREELHRHE DRHRAMAVAL RRSGPAVLAS AGTIAVGLVC LALADVNSSR
SMGLVGAVGV VCGFLAMVTV LPALLVIAGR WVFWPFVPRY GTPARKARTV WSRVGAAVAR
HPRWSWLMSA AVTCVLALSA TGIGMGLQQS EMFQDKPESV VAQERISAHY PSGAADPARI
VVKADRAAEV GALVSEVPGV ARVENGGRTP GGELAALSVV LADTPDSGAA KDTVDRLRTA
VHSVDGAEAL VGGTTAQTLD TQRAAARDLR TVIPAVLAVV LLVLVWLLRS LVGPLLLLGT
VVLSYFAALG ASNLLFEHVL GHAGVDWSIP LMGFVFLVAL GIDYNIFLMH RVREETGRAG
HVRGVLEGLT STGGVITSAG VVLAATFAVF AGLPLVTMAQ MGVLVGIGVL LDTFLVRTVL
VPALALDLGR WFWWPGRLFR ELGRPDGLPR TSGEREHAPV
//
