ID A0A1G9S8W8_9ACTO Unreviewed; 480 AA.
AC A0A1G9S8W8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN ORFNames=SAMN04487766_101341 {ECO:0000313|EMBL:SDM31757.1},
GN SAMN05216355_102100 {ECO:0000313|EMBL:SDN36252.1};
OS Actinomyces ruminicola.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=332524 {ECO:0000313|EMBL:SDM31757.1, ECO:0000313|Proteomes:UP000199671};
RN [1] {ECO:0000313|Proteomes:UP000198541, ECO:0000313|Proteomes:UP000199671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27982 {ECO:0000313|EMBL:SDN36252.1,
RC ECO:0000313|Proteomes:UP000198541}, and KPR-7B
RC {ECO:0000313|EMBL:SDM31757.1, ECO:0000313|Proteomes:UP000199671};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity.
CC {ECO:0000256|ARBA:ARBA00002835, ECO:0000256|RuleBase:RU362085}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU362085};
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
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DR EMBL; FNHU01000001; SDM31757.1; -; Genomic_DNA.
DR EMBL; FNIM01000002; SDN36252.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G9S8W8; -.
DR STRING; 332524.SAMN04487766_101341; -.
DR Proteomes; UP000198541; Unassembled WGS sequence.
DR Proteomes; UP000199671; Unassembled WGS sequence.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR CDD; cd00984; DnaB_C; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007692; DNA_helicase_DnaB.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00665; DnaB; 1.
DR PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF03796; DnaB_C; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU362085};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW Helicase {ECO:0000256|RuleBase:RU362085, ECO:0000313|EMBL:SDM31757.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362085}; Primosome {ECO:0000256|RuleBase:RU362085}.
FT DOMAIN 202..473
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
SQ SEQUENCE 480 AA; 52848 MW; 9F96D0E064563AA7 CRC64;
MTDVDTIGAR TRGEERPVDA RYDGAFDRVP PQDLEAEMST LGGMLLSKEA ITDVIEVLRG
PEFYKPAHES IFDAIVEVYN RSEPADPLIV ADELSKRGEL ERVGGAPYLA SLMATVPTAA
NAAYYARIVK EKSLMRGLVQ AGTRIAQLGY STDAGDIDEL VTLAESEVYA VAHKEGERED
YVPVGELLNE ANLEIEAGQA REDGQMRGVP TGFVELDELL GGLHGGQMII VAARPAMGKS
TLAVDFCRSA SIHSRGADGN LIPSCYFSLE MGRMELMMRI LSAESGVAMN KLRGGSQMDE
RDWEDVARAY NPVSEAPLFI DDSPNLTMPE IRSKALRLKQ HHGLGLMVVD YLQLMSSGKQ
VESRQQEVSE FSRSLKLLAK ELDIPVVAVA QLNRGPEQRT GNKPQMSDLR ESGSLEQDAD
VIMLLHRPEY YQEEERPGEA DIIVAKHRNG QTRTIPVAFQ GHLSRFANMA RNITPEPAYE
//
