ID A0A1G9SIG2_9SPHI Unreviewed; 1451 AA.
AC A0A1G9SIG2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SDM35286.1};
GN ORFNames=SAMN05421813_11076 {ECO:0000313|EMBL:SDM35286.1};
OS Daejeonella rubra.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Daejeonella.
OX NCBI_TaxID=990371 {ECO:0000313|EMBL:SDM35286.1, ECO:0000313|Proteomes:UP000199226};
RN [1] {ECO:0000313|Proteomes:UP000199226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24536 {ECO:0000313|Proteomes:UP000199226};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; FNHH01000010; SDM35286.1; -; Genomic_DNA.
DR STRING; 990371.SAMN05421813_11076; -.
DR OrthoDB; 9760604at2; -.
DR Proteomes; UP000199226; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 878..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1008..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1046..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1451 AA; 160629 MW; 801578C97A712398 CRC64;
MLNAIIEFSV KNKLIIGLFV IGLIVYGSYQ ATKLPIDAVP DITNNQVQVI TVAPSFGATD
IERLVTFPIE QANSNIKGLK EIRSFSRFGL SLVTIVFEDG IDIYWARQQV AERLQKVQTE
IPPGIGTPEL GPISTGLGEI YQYVVRPKDG YEAKYDATEL RTIQDWIVRR QLLGVKGVAE
VSSFGGKLKQ YEISIDPNKL QSFNITINDV FTALERNNQN TGGAYIEKGP TVLFVRSEGL
IGNTSDIEKI NIKSSENGTP VFIRDVAQIN IGYATRYGAM TYNDKGEVSG AVVMMLKDAN
SSEVIKNVKE RIELIQKTLP EGVIIEPFLD RTKMVNNAIF TVEKNLIEGA LIVVFILVLF
LGNFRAGLLV ASVIPLAMLF AIILMNLFKV SGNLMSLGAL DFGLIVDGAV IIVEAVMHQL
SHSKKFGLVN RLSQSDMDGE VKKSASKMMN SAVFGQIIIL IVYLPIFTLQ GIEGKMFKPM
AQTVAFALLG AFILSLTYIP MMSAWFLSKK IKHEPNLSDK IMFKVEAFYQ HQLSRVLRFP
KMVLGTVVAL FIMALVVLSN LGGEFIPALE EGDFAVDTRV LTGSNLNTTI ESTTKAAHIL
KTQFPEVIKV VTKIGSGEVP TDPMPMEASD MMVIMKDKSE WTTAKTFDEM AAKMGKALED
VPGITAGFQY PVQMRFNELM TGARQDVVLK IFGENLDTLA YYAESLGKIV NEVEGSQDLF
VEPVTGMPQI VIEYNRDAIA QYNLNIADIN RVVNTAFAGQ SSGLVFEGEK RFDLMVRLNT
DKRKNLDDVR NLLIPTPQGT NIPLNQLAQV DIKNGPNQIQ REDAKRRIVV GFNVRGRDVQ
SIVNELQMKV NERINLPAGY YVTYGGAFEN LNAAKERLMI AVPVSLLLIF ILLFFAFNSV
KQGLIIYTAI PLSAIGGIYF LALRGMPFSI SAGIGFIALF GVAVLNGIVL IAEFNRLKDS
GQTDLRRIVL MGTKIRLRPV LMTAFVASLG FLPMALSSGA GAEVQKPLAT VVIGGLMIAT
LLTLFVLPIL YILFEGSADK KSSKHIAVVV LILCLTGFNN VNAQEKIGLQ AAIDTALKNN
RGFKNEQLKS EYQQKLIKSS ANIPQATLSS EFGQINSIYS DTRFGLSQSF SFPTVYSNQK
KLLNEEWKAS VLSISLKEAE IRRTVTQIFY SILILNEKEK LLIQADSIYS GFLNKAELRF
KTGESNILER ATAKTQRGGI FLQLKSLQEE IELAKLQFQL VLNTGIKTEP EEIRPRMQLS
TSLDAPILAG HPLLKISDQQ KLIASANSKL EKSRFLPDLS LGYFNTSIKG TGANDVYYPS
SKRFGSAYIG IGIPIFTSSQ KARVNASALS EKIAENNYQT QLSTLETQYQ SARSQYETYL
AALTYYEEFS MPEANIIRQT ADKQFINGEI NYLEWVMLNN QAIVIQNNHL DIIKSLNESI
INLNYLSSKE K
//
