ID   A0A1G9U4F0_9EURY        Unreviewed;       686 AA.
AC   A0A1G9U4F0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Formate dehydrogenase major subunit {ECO:0000313|EMBL:SDM54771.1};
GN   ORFNames=SAMN04487949_2032 {ECO:0000313|EMBL:SDM54771.1};
OS   Halogranum gelatinilyticum.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae.
OX   NCBI_TaxID=660521 {ECO:0000313|EMBL:SDM54771.1, ECO:0000313|Proteomes:UP000199451};
RN   [1] {ECO:0000313|Proteomes:UP000199451}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.10119 {ECO:0000313|Proteomes:UP000199451};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNHL01000002; SDM54771.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9U4F0; -.
DR   STRING; 660521.SAMN04487949_2032; -.
DR   OrthoDB; 23466at2157; -.
DR   Proteomes; UP000199451; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR   CDD; cd00508; MopB_CT_Fdh-Nap-like; 1.
DR   CDD; cd02753; MopB_Formate-Dh-H; 1.
DR   Gene3D; 2.40.40.20; -; 1.
DR   Gene3D; 3.40.50.740; -; 1.
DR   Gene3D; 2.20.25.90; ADC-like domains; 1.
DR   Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR041924; Formate_Dh-H_N.
DR   InterPro; IPR006478; Formate_DH_asu.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR   InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR   NCBIfam; TIGR01591; Fdh-alpha; 1.
DR   PANTHER; PTHR43105:SF15; FORMATE DEHYDROGENASE H; 1.
DR   PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR   Pfam; PF04879; Molybdop_Fe4S4; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   SMART; SM00926; Molybdop_Fe4S4; 1.
DR   SUPFAM; SSF50692; ADC-like; 1.
DR   SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR   PROSITE; PS00490; MOLYBDOPTERIN_PROK_2; 1.
DR   PROSITE; PS00932; MOLYBDOPTERIN_PROK_3; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199451}.
FT   DOMAIN          4..55
FT                   /note="4Fe-4S Mo/W bis-MGD-type"
FT                   /evidence="ECO:0000259|SMART:SM00926"
SQ   SEQUENCE   686 AA;  73077 MW;  0EBB687B564E86C7 CRC64;
     MSPPTPRESV CPFCGVGCGI QYNPTNGKAV GWHGAVNTRG EVCPKGVAAF DVVGHEDRLT
     RPLVRGDDGQ LHEATWDEAL LRVETAFGEI VAEHGPDALA FFASSNCTNE ENYVFQKLAR
     LLGTNNVDNC ARLCHASTVA AMSDRLGAGA MTNSLTDLRD HADCFLVVGA NPAEQHPIVF
     RSYVLPALAR GATLIHVDPR ENATTDAADL HLPVRPGYDI PLLNAMAKVV VEEGLVDRDF
     LTERVTGDED FRAFLDGVDV DREAGRAGVD PDLVREAART YAGAGNATTF TGMGMSQHHY
     GTDNVHALVN LALLTGNLGK PGAGVNPLRG QNNVQGAGDV GALPNLLPGY ADVTDDAARA
     RVADEWGVDA DDLPALPGLT EVETTHAFGD SVHGAFVFGE NPLVTEPNLA RVREGFANLD
     CLVVLDIFPT ETAELADVVL PGSAWAEKDG TVTNTDRQVQ RMRPNADLPG DARRDLDILC
     DLGRRLTGRE DQFGCDGPEA VFAELTRVTP QYAGMSYDGI GTGSQRWPFP EGASEGTAVL
     HVDEFASGSK TAKLRPVVHV DPADSVADDE LVLTTGRVLQ QFNSGAVTRR SGMLTRLRGS
     DVLQIHPDDA GSRGIADGDR VVVENDRGTV TVAAEVTPAI RPGVVFATFH YAEPLINDLT
     GDALDPVAKI PEFKHSAVRV RVADDV
//