ID   A0A1G9UHY6_9ACTN        Unreviewed;       503 AA.
AC   A0A1G9UHY6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Cell volume regulation protein A {ECO:0000313|EMBL:SDM59531.1};
GN   ORFNames=SAMN05660642_02810 {ECO:0000313|EMBL:SDM59531.1};
OS   Geodermatophilus siccatus.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Geodermatophilus.
OX   NCBI_TaxID=1137991 {ECO:0000313|EMBL:SDM59531.1, ECO:0000313|Proteomes:UP000198680};
RN   [1] {ECO:0000313|EMBL:SDM59531.1, ECO:0000313|Proteomes:UP000198680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45419 {ECO:0000313|EMBL:SDM59531.1,
RC   ECO:0000313|Proteomes:UP000198680};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FNHE01000007; SDM59531.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1G9UHY6; -.
DR   STRING; 1137991.SAMN05660642_02810; -.
DR   OrthoDB; 9810759at2; -.
DR   Proteomes; UP000198680; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR   PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR   PROSITE; PS51202; RCK_C; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        35..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        59..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        267..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        301..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        366..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          401..483
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
SQ   SEQUENCE   503 AA;  52226 MW;  98BC4F0A9A2C770A CRC64;
     MNSTVTVALA AGAVVVLVAA VALRLADRLG LPSLLLYLAL GVAIGESGLG VQFEDYRLTH
     TLAYAALVVI LAEGGLTTRW GDVRRAIGPG VSLSTVGVAV SVVVTAAVGV LVLGYDWGFA
     LLLAAVISST DAAAVFATLR RLPLPRRLAA SLEAESGLND APVILLVTVL AESLTGATTL
     PWWLVGLEVA AELAGGAVIG IGIGFGGAAL LRRVALPVAG FYPLATLALC VLAYSSASLA
     HTSGFVAVYL CGLVLGNAAL PHRAASIGFA EGMASLAQIG LFVLLGLLVS PGRLSDAVGP
     ALVVGGALLL LARPLSVVAS LVWFRFPWAQ QVFISWAGLR GAVPIVAAII PLTMQVPGAR
     TVFDTVFVLV VVFTIVQGWS LPWLARRLRI ATPVTPRDVQ VEAAPLEELD AELMQLTVPE
     GSRLHGVYLP ELRLPEDAAV VLIVRDGRSF VPGPTTRLMR GDQALLVSTR GSRAEAERRL
     RAVSRAGRLA TWRGETGAAS EAD
//